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Genetically encoded singlet oxygen photosensitizers

Research output: Book chapterChapterpeer-review

Abstract

The ability to selectively control the site of singlet-oxygen (1O2) production in a cell is crucial for inflicting photodynamic damage in a desired location. Genetically encoded photosensitizers, which can be fused to virtually any protein and are expressed in a cell without the need to add any external cofactors, offer absolute control of the 1O2 production site. This chapter provides a molecular view of the photosensitization mechanisms in two families of genetically encoded photosensitizers: green fluorescent protein variants and flavoproteins. It also covers the main applications of these proteins in areas such as photodynamic therapy and chromophore-assisted laser inactivation, as well as in advanced imaging techniques.
Translated title of the contributionChapter 13 Genetically encoded singlet oxygen photosensitizers
Original languageEnglish
Title of host publicationSinglet Oxygen. Applications in Biosciences and Nanosciences
EditorsSanti Nonell, Cristina Flors
PublisherRoyal Society of Chemistry
Chapter13
Pages271-286
Number of pages15
Volume1
ISBN (Electronic)978-1-78262-801-9, 978-1-78262-220-8
ISBN (Print)978-1-78262-038-9
DOIs
Publication statusPublished - Jan 2016

Publication series

NameComprehensive Series in Photochemical & Photobiological Sciences
ISSN (Print)2041-9716
ISSN (Electronic)2041-9724

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