Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography

M. Quintela; J. Báguena; G. Gotor; M. J. Blanco; F. Broto

doi:10.1016/j.chroma.2011.11.064

Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography

M. Quintela, J. Báguena, G. Gotor, M. J. Blanco, F. Broto

IQS School of Engineering

Research output: Indexed journal article › Article › peer-review

20 Citations (Scopus)

Abstract

This article presents a model to calculate the uncertainty associated with an analytical result based on the validation of the analysis procedure. This calculation model is proposed as an alternative to commonly used. bottom-up and. top-down methods. This proposal is very advantageous as the validation of the procedures and the estimation of the uncertainty of the measurement are part of the technical requirements needed in order to obtain the ISO 17025:2005 accreditation. This model has been applied to the determination of chloride by liquid chromatography in lixiviates and in the determination of palmitic acid and stearic acid by gas chromatography in magnesium stearate samples.

Original language	English
Pages (from-to)	107-117
Number of pages	11
Journal	Journal of Chromatography A
Volume	1223
DOIs	https://doi.org/10.1016/j.chroma.2011.11.064
Publication status	Published - 3 Feb 2012

Keywords

Gas chromatography
Liquid chromatography
Uncertainty
Validation

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Quintela, M., Báguena, J., Gotor, G., Blanco, M. J., & Broto, F. (2012). Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography. Journal of Chromatography A, 1223, 107-117. https://doi.org/10.1016/j.chroma.2011.11.064

Quintela, M. ; Báguena, J. ; Gotor, G. et al. / Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures : Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography. In: Journal of Chromatography A. 2012 ; Vol. 1223. pp. 107-117.

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abstract = "This article presents a model to calculate the uncertainty associated with an analytical result based on the validation of the analysis procedure. This calculation model is proposed as an alternative to commonly used. bottom-up and. top-down methods. This proposal is very advantageous as the validation of the procedures and the estimation of the uncertainty of the measurement are part of the technical requirements needed in order to obtain the ISO 17025:2005 accreditation. This model has been applied to the determination of chloride by liquid chromatography in lixiviates and in the determination of palmitic acid and stearic acid by gas chromatography in magnesium stearate samples.",

keywords = "Gas chromatography, Liquid chromatography, Uncertainty, Validation",

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Quintela, M, Báguena, J , Gotor, G , Blanco, MJ & Broto, F 2012, 'Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography', Journal of Chromatography A, vol. 1223, pp. 107-117. https://doi.org/10.1016/j.chroma.2011.11.064

Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography. / Quintela, M.; Báguena, J.; Gotor, G. et al.
In: Journal of Chromatography A, Vol. 1223, 03.02.2012, p. 107-117.

Research output: Indexed journal article › Article › peer-review

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T1 - Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures

T2 - Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography

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AU - Báguena, J.

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AU - Blanco, M. J.

AU - Broto, F.

PY - 2012/2/3

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N2 - This article presents a model to calculate the uncertainty associated with an analytical result based on the validation of the analysis procedure. This calculation model is proposed as an alternative to commonly used. bottom-up and. top-down methods. This proposal is very advantageous as the validation of the procedures and the estimation of the uncertainty of the measurement are part of the technical requirements needed in order to obtain the ISO 17025:2005 accreditation. This model has been applied to the determination of chloride by liquid chromatography in lixiviates and in the determination of palmitic acid and stearic acid by gas chromatography in magnesium stearate samples.

AB - This article presents a model to calculate the uncertainty associated with an analytical result based on the validation of the analysis procedure. This calculation model is proposed as an alternative to commonly used. bottom-up and. top-down methods. This proposal is very advantageous as the validation of the procedures and the estimation of the uncertainty of the measurement are part of the technical requirements needed in order to obtain the ISO 17025:2005 accreditation. This model has been applied to the determination of chloride by liquid chromatography in lixiviates and in the determination of palmitic acid and stearic acid by gas chromatography in magnesium stearate samples.

KW - Gas chromatography

KW - Liquid chromatography

KW - Uncertainty

KW - Validation

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Quintela M, Báguena J , Gotor G , Blanco MJ , Broto F. Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography. Journal of Chromatography A. 2012 Feb 3;1223:107-117. doi: 10.1016/j.chroma.2011.11.064

Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: Application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography

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Keywords

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