TY - JOUR
T1 - Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study
AU - Jakszyn, Paula
AU - Bingham, Sheila
AU - Pera, Guillem
AU - Agudo, Antonio
AU - Luben, Robert
AU - Welch, Ailsa
AU - Boeing, Heiner
AU - del Giudice, Giuseppe
AU - Palli, Domenico
AU - Saieva, Calogero
AU - Krogh, Vittorio
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Berglund, Göran
AU - Simán, Henrik
AU - Hallmans, Göran
AU - Sanchez, María José
AU - Larrañaga, Nerea
AU - Barricarte, Aurelio
AU - Chirlaque, María Dolores
AU - Quirós, José R.
AU - Key, Timothy J.
AU - Allen, Naomi
AU - Lund, Eiliv
AU - Carneiro, Fátima
AU - Linseisen, Jakob
AU - Nagel, Gabriele
AU - Overvad, Kim
AU - Tjonneland, Anne
AU - Olsen, Anja
AU - Bueno-de-Mesquita, H. Bas
AU - Ocké, Marga O.
AU - Peeters, Petra H.M.
AU - Numans, Mattijs E.
AU - Clavel-Chapelon, Françoise
AU - Trichopoulou, Antonia
AU - Fenger, Claus
AU - Stenling, Roger
AU - Ferrari, Pietro
AU - Jenab, Mazda
AU - Norat, Teresa
AU - Riboli, Elio
AU - Gonzalez, Carlos A.
N1 - Funding Information:
The EPIC study was funded by ‘Europe Against Cancer’ Programme of the European Commission (SANCO); Ligue contre le Cancer (France); Société 3M (France); Mutuelle Générale de l’Education Nationale; Institut National de la Santé et de la Recherche Médicale (INSERM); German Cancer Aid; German Cancer Research Center; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health (RCESP-C03/09); the participating regional governments and institutions of Spain; Cancer Research, UK; Medical Research Council, UK; the Stroke Association, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; the Wellcome Trust, UK; Greek Ministry of Health; Greek Ministry of Education; Italian Association for Research on Cancer; Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; Dutch Ministry of Health; Dutch Prevention Funds; LK Research Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden; Norwegian Cancer Society. We thank the members of the panel of pathologists for their valuable work: Dr R.S. Umea, Sweden; Dr U. Mahlke, Postdam, Germany; Dr Hendrik Bläker, Heildelberg, Germany; Dr Gabriella Nesi, Firenze, Italy; Dr Vicki Save, Cambridge, UK; Dr Claus Fenger, Copenhagen, Denmark; Dr Julio Torrado, San Sebastian, Spain; Dr Johan Offerhaus, Amsterdam, The Netherlands; Ioannina, Greece. We also thank Dr Dimitrious Roukos and Cátia Moutinho, Porto, Portugal, for her excellent technical support to the panel of pathologists. Specific study results of the nested case–control study within EPIC (EUR-GAST) were obtained with financial support from the FP5 of European Commission (QLG1-CT-2001-01049). The participation of P.J. in the project is supported by a grant of the ‘Fundació Privada Institut d’Investigació Biomèdica de Bellvitge (IDIBELL).
PY - 2006/7
Y1 - 2006/7
N2 - The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was <1 μg on average compared with 93 μg on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 μg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction - 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.
AB - The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was <1 μg on average compared with 93 μg on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 μg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction - 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.
UR - https://www.scopus.com/pages/publications/33745596410
U2 - 10.1093/carcin/bgl019
DO - 10.1093/carcin/bgl019
M3 - Article
C2 - 16571648
AN - SCOPUS:33745596410
SN - 0143-3334
VL - 27
SP - 1497
EP - 1501
JO - Carcinogenesis
JF - Carcinogenesis
IS - 7
ER -
SDG 3 Good Health and Well-being