Abstract
An efficient synthesis of trans-2-phenylcyclohexanol has been achieved by enantioselective protonation of the enolate of 2-phenylcyclohexanone with α-sulfinyl alcohols and subsequent reduction of the chiral ketone by sodium naphthalenide in the presence of acetamide. Interestingly, the chirality source is not consumed in the synthesis of the chiral target.
Original language | English |
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Pages (from-to) | 3939-3940 |
Number of pages | 2 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 20 |
DOIs | |
Publication status | Published - 14 May 1999 |
Externally published | Yes |
Keywords
- Alpha-sulfinyl alcohols
- Protonation
- Alkylation