Efficient system for the preparation of [13N]labeled nitrosamines

Vanessa Gómez-Vallejo; Koichi Kato; Masayuki Hanyu; Katsuyuki Minegishi; José I. Borrell; Jordi Llop

doi:10.1016/j.bmcl.2009.02.066

Efficient system for the preparation of [¹³N]labeled nitrosamines

Vanessa Gómez-Vallejo
, Koichi Kato
, Masayuki Hanyu
, Katsuyuki Minegishi
, José I. Borrell
, Jordi Llop^*

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

13 Citations (Scopus)

Abstract

In the present Letter, a fast and reproducible method for the synthesis of N-[¹³N]nitrosamines is reported. The labeling strategy is based on trapping [¹³N]NO₂^- in an anion exchange resin. The reaction with secondary amines in the presence of Ph₃P and Br₂ led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

Original language	English
Pages (from-to)	1913-1915
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.066
Publication status	Published - 1 Apr 2009

Keywords

Nitrogen-13
Nitrosamines
Positron emission tomography

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10.1016/j.bmcl.2009.02.066

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title = "Efficient system for the preparation of [13N]labeled nitrosamines",

abstract = "In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45\%). Final radiotracers were obtained after purification in good radiochemical yields (>30\%, decay corrected). Radiochemical purity was above 99\% in all cases.",

keywords = "Nitrogen-13, Nitrosamines, Positron emission tomography",

author = "Vanessa G{\'o}mez-Vallejo and Koichi Kato and Masayuki Hanyu and Katsuyuki Minegishi and Borrell, \{Jos{\'e} I.\} and Jordi Llop",

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T1 - Efficient system for the preparation of [13N]labeled nitrosamines

AU - Gómez-Vallejo, Vanessa

AU - Kato, Koichi

AU - Hanyu, Masayuki

AU - Minegishi, Katsuyuki

AU - Borrell, José I.

AU - Llop, Jordi

PY - 2009/4/1

Y1 - 2009/4/1

N2 - In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

AB - In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

KW - Nitrogen-13

KW - Nitrosamines

KW - Positron emission tomography

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M3 - Article

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EP - 1915

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Efficient system for the preparation of [¹³N]labeled nitrosamines

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Keywords

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