Abstract
A new synthesis of (-)-(R)-muscone ((R)-1) by means of enantioselective protonation of a bicyclic ketone enolate as the key step (see 6 → (S)-4 in Scheme 2) is presented. The C15 macrocyclic system is obtained by ozonolysis (Scheme 7).
Original language | English |
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Pages (from-to) | 1737-1747 |
Number of pages | 11 |
Journal | Helvetica Chimica Acta |
Volume | 87 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2004 |
Externally published | Yes |
Keywords
- Conjugate addition
- Asymmetric protonation
- Olefin synthesis
- Acyclic enones
- Hydrogenation
- (r)-muscone
- Fragmentaation
- Derivatives
- (s)-muscone
- Ligand