Efficient synthesis of (-)-(R)-muscone by enantioselective protonation

Charles Fehr, José Galindo, Iris Farris, Ana Cuenca

Research output: Indexed journal article Articlepeer-review

30 Citations (Scopus)


A new synthesis of (-)-(R)-muscone ((R)-1) by means of enantioselective protonation of a bicyclic ketone enolate as the key step (see 6 → (S)-4 in Scheme 2) is presented. The C15 macrocyclic system is obtained by ozonolysis (Scheme 7).

Original languageEnglish
Pages (from-to)1737-1747
Number of pages11
JournalHelvetica Chimica Acta
Issue number7
Publication statusPublished - 2004
Externally publishedYes


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