Efficient asymmetric protonation of enolates with readily accessible chiral α-sulfinyl alcohols

Gregorio Asensio, Pedro Alemán, Ana Cuenca, Jesús Gil, Mercedes Medio-Simón

Research output: Indexed journal article Articlepeer-review

27 Citations (Scopus)

Abstract

The efficient asymmetric protonation of lithium enolates of 2- alkylcycloalkanones (87-96% ee) with readily accessible chiral α-sulfinyl alcohols is described. Optimal stereoselection is achieved for each lithium enolate at a different reaction temperature in the range -40 to -100°C.

Original languageEnglish
Pages (from-to)4073-4078
Number of pages6
JournalTetrahedron Asymmetry
Volume9
Issue number22
DOIs
Publication statusPublished - 27 Nov 1998
Externally publishedYes

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