Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial

Maria Rosa Rifà Ros; Àngels Pallarés Martí; Miriam Rodríguez Monforte; Genís Carrasco; Youssef  Nava; Oriol  Pallarés; Isabel Pérez-Pérez

doi:doi.org/10.33500/jmphtr.2015.3.003

Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial

Maria Rosa Rifà Ros, Àngels Pallarés Martí, Miriam Rodríguez Monforte, Genís Carrasco, Youssef Nava, Oriol Pallarés, Isabel Pérez-Pérez

Blanquerna School of Health Sciences

Research output: Indexed journal article › Article

Abstract

Recent randomized controlled trials have demonstrated the utility of stevioside and related compounds, extracted and refined from stevia leaf plant, to improve blood glucose and blood pressure in patients with type 2 diabetes. However, up till date, no well-designed trials have shown that the dried leaves of the stevia plant have similar effects in medical use. A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes. One hundred and fourteen patients (80 women and 34 men) participated in a cross-over study consisting of an intake of tea sweetened with dried leaves of S. rebaudiana (study group) or refined sugar (control group), after a wash out period of two days. Capillary blood glucose, hearth rate and blood pressure were then determined at minutes 0 (baseline), 30, 60, 120 and 240 after the ingestion. In all patients, blood glucose reduction of -35.8% (95%CI -27.0 to -44.6%) were observed in the S. rebaudiana group compared to an increase in the control group (+8.1%, 95%CI 3.1 to 13.2% [p

Translated title of the contribution	Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial
Original language	English
Pages (from-to)	16-26
Number of pages	11
Journal	Jornal of medicinal plant and herbal Therapy Research
Volume	3
Issue number	2
DOIs	https://doi.org/doi.org/10.33500/jmphtr.2015.3.003
Publication status	Published - 1 Jun 2015

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Rifà Ros, M. R., Pallarés Martí, À., Rodríguez Monforte, M., Carrasco, G., Nava, Y., Pallarés, O., & Pérez-Pérez, I. (2015). Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial. Jornal of medicinal plant and herbal Therapy Research, 3(2), 16-26. https://doi.org/doi.org/10.33500/jmphtr.2015.3.003

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title = "Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial",

abstract = "Recent randomized controlled trials have demonstrated the utility of stevioside and related compounds, extracted and refined from stevia leaf plant, to improve blood glucose and blood pressure in patients with type 2 diabetes. However, up till date, no well-designed trials have shown that the dried leaves of the stevia plant have similar effects in medical use. A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes. One hundred and fourteen patients (80 women and 34 men) participated in a cross-over study consisting of an intake of tea sweetened with dried leaves of S. rebaudiana (study group) or refined sugar (control group), after a wash out period of two days. Capillary blood glucose, hearth rate and blood pressure were then determined at minutes 0 (baseline), 30, 60, 120 and 240 after the ingestion. In all patients, blood glucose reduction of -35.8% (95%CI -27.0 to -44.6%) were observed in the S. rebaudiana group compared to an increase in the control group (+8.1%, 95%CI 3.1 to 13.2% [p",

author = "{Rif{\`a} Ros}, {Maria Rosa} and {Pallar{\'e}s Mart{\'i}}, {\`A}ngels and {Rodr{\'i}guez Monforte}, Miriam and Gen{\'i}s Carrasco and Youssef Nava and Oriol Pallar{\'e}s and Isabel P{\'e}rez-P{\'e}rez",

note = "Pallar{\'e}s, A; Carrasco, A; Nava, Y; Pallar{\'e}s, O; P{\'e}rez, I; Rif{\`a}, I; Rodr{\'i}guez, M",

year = "2015",

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doi = "doi.org/10.33500/jmphtr.2015.3.003",

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Rifà Ros, MR, Pallarés Martí, À, Rodríguez Monforte, M, Carrasco, G, Nava, Y, Pallarés, O & Pérez-Pérez, I 2015, 'Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial', Jornal of medicinal plant and herbal Therapy Research, vol. 3, no. 2, pp. 16-26. https://doi.org/doi.org/10.33500/jmphtr.2015.3.003

Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial. / Rifà Ros, Maria Rosa; Pallarés Martí, Àngels; Rodríguez Monforte, Miriam et al.
In: Jornal of medicinal plant and herbal Therapy Research, Vol. 3, No. 2, 01.06.2015, p. 16-26.

Research output: Indexed journal article › Article

TY - JOUR

T1 - Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial

AU - Rifà Ros, Maria Rosa

AU - Pallarés Martí, Àngels

AU - Rodríguez Monforte, Miriam

AU - Carrasco, Genís

AU - Nava, Youssef

AU - Pallarés, Oriol

AU - Pérez-Pérez, Isabel

N1 - Pallarés, A; Carrasco, A; Nava, Y; Pallarés, O; Pérez, I; Rifà, I; Rodríguez, M

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Recent randomized controlled trials have demonstrated the utility of stevioside and related compounds, extracted and refined from stevia leaf plant, to improve blood glucose and blood pressure in patients with type 2 diabetes. However, up till date, no well-designed trials have shown that the dried leaves of the stevia plant have similar effects in medical use. A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes. One hundred and fourteen patients (80 women and 34 men) participated in a cross-over study consisting of an intake of tea sweetened with dried leaves of S. rebaudiana (study group) or refined sugar (control group), after a wash out period of two days. Capillary blood glucose, hearth rate and blood pressure were then determined at minutes 0 (baseline), 30, 60, 120 and 240 after the ingestion. In all patients, blood glucose reduction of -35.8% (95%CI -27.0 to -44.6%) were observed in the S. rebaudiana group compared to an increase in the control group (+8.1%, 95%CI 3.1 to 13.2% [p

AB - Recent randomized controlled trials have demonstrated the utility of stevioside and related compounds, extracted and refined from stevia leaf plant, to improve blood glucose and blood pressure in patients with type 2 diabetes. However, up till date, no well-designed trials have shown that the dried leaves of the stevia plant have similar effects in medical use. A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes. One hundred and fourteen patients (80 women and 34 men) participated in a cross-over study consisting of an intake of tea sweetened with dried leaves of S. rebaudiana (study group) or refined sugar (control group), after a wash out period of two days. Capillary blood glucose, hearth rate and blood pressure were then determined at minutes 0 (baseline), 30, 60, 120 and 240 after the ingestion. In all patients, blood glucose reduction of -35.8% (95%CI -27.0 to -44.6%) were observed in the S. rebaudiana group compared to an increase in the control group (+8.1%, 95%CI 3.1 to 13.2% [p

UR - http://www.bluepenjournals.org/jmphtr/abstract/2015/June/Pallares_et_al.php

U2 - doi.org/10.33500/jmphtr.2015.3.003

DO - doi.org/10.33500/jmphtr.2015.3.003

M3 - Article

SN - 2053-1826

VL - 3

SP - 16

EP - 26

JO - Jornal of medicinal plant and herbal Therapy Research

JF - Jornal of medicinal plant and herbal Therapy Research

IS - 2

ER -

Rifà Ros MR, Pallarés Martí À, Rodríguez Monforte M, Carrasco G, Nava Y, Pallarés O et al. Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial. Jornal of medicinal plant and herbal Therapy Research. 2015 Jun 1;3(2):16-26. doi: doi.org/10.33500/jmphtr.2015.3.003

Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial

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