DNA Methylation and High-Density Lipoprotein Functionality-Brief Report: The REGICOR Study (Registre Gironi del Cor)

Sergi Sayols-Baixeras, Alvaro Hernáez, Issac Subirana, Carla Lluis-Ganella, Daniel Muñoz, Montserrat Fitó, Jaume Marrugat, Roberto Elosua

Research output: Indexed journal article Articlepeer-review

9 Citations (Scopus)

Abstract

Objective-The function of high-density lipoproteins (HDLs) may better reflect their atheroprotective role, compared with HDL-cholesterol levels. The association between DNA methylation and HDL function has not yet been established. Approach and Results-We designed an epigenome-wide association study including 645 individuals from the REGICOR study (Registre Gironi del Cor). We determined DNA methylation from peripheral blood cells using the HumanMethylation450 array. We analyzed HDL functionality by determining HDL cholesterol efflux capacity and HDL inflammatory index. We discovered 3 methylation sites located in HOXA3, PEX5, and PER3 related to cholesterol efflux capacity and 1 located in GABRR1 related to HDL inflammatory index. Using a candidate gene approach, we also found 2 methylation sites located in CMIP related to cholesterol efflux capacity. Conclusions-We identified 6 potential loci associated with HDL functionality in HOXA3, PEX5, PER3, CMIP, and GABRR1. Additional studies are warranted to validate these findings in other populations.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume37
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Keywords

  • DNA methylation
  • atherosclerosis
  • blood cells
  • lipoproteins
  • risk factors

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