Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Mauro Serafini; Paula Jakszyn; Leila Luján-Barroso; Antonio Agudo; H. Bas Bueno-De-Mesquita; Fränzel J.B. Van Duijnhoven; Mazda Jenab; Carmen Navarro; Domenico Palli; Heiner Boeing; Peter Wallström; Sara Regnér; Mattijs E. Numans; Fatima Carneiro; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Sophie Morois; Sara Grioni; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; José Ramon Quirõs; Esther Molina-Montes; Jose M. Huerta Castaño; Aurelio Barricarte; Pilar Amiano; Kay Tee Khaw; Nicholas Wareham; Naomi E. Allen; Timothy J. Key; Suzanne M. Jeurnink; Petra H.M. Peeters; Christina Bamia; Elisabeth Valanou; Antonia Trichopoulou; Rudolf Kaaks; Annekatrin Lukanova; Manuela M. Bergmann; Björn Lindkvist; Roger Stenling; Ingegerd Johansson; Christina C. Dahm; Kim Overvad; Majken Jensen; Anja Olsen; Anne Tjonneland; Eiliv Lund; Sabina Rinaldi; Dominique Michaud; Traci Mouw; Elio Riboli; Carlos A. González

doi:10.1002/ijc.27347

Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Mauro Serafini, Paula Jakszyn, Leila Luján-Barroso, Antonio Agudo, H. Bas Bueno-De-Mesquita, Fränzel J.B. Van Duijnhoven, Mazda Jenab, Carmen Navarro, Domenico Palli, Heiner Boeing, Peter Wallström, Sara Regnér, Mattijs E. Numans, Fatima Carneiro, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Sophie Morois, Sara Grioni, Salvatore Panico, Rosario TuminoCarlotta Sacerdote, José Ramon Quirõs, Esther Molina-Montes, Jose M. Huerta Castaño, Aurelio Barricarte, Pilar Amiano, Kay Tee Khaw, Nicholas Wareham, Naomi E. Allen, Timothy J. Key, Suzanne M. Jeurnink, Petra H.M. Peeters, Christina Bamia, Elisabeth Valanou, Antonia Trichopoulou, Rudolf Kaaks, Annekatrin Lukanova, Manuela M. Bergmann, Björn Lindkvist, Roger Stenling, Ingegerd Johansson, Christina C. Dahm, Kim Overvad, Majken Jensen, Anja Olsen, Anne Tjonneland, Eiliv Lund, Sabina Rinaldi, Dominique Michaud, Traci Mouw, Elio Riboli, Carlos A. González

Research output: Indexed journal article › Article › peer-review

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Abstract

A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28-0.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.21-0.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.

Original language	English
Pages (from-to)	E544-E554
Journal	International Journal of Cancer
Volume	131
Issue number	4
DOIs	https://doi.org/10.1002/ijc.27347
Publication status	Published - 15 Aug 2012
Externally published	Yes

Keywords

antioxidant capacity
diet
longitudinal studies
stomach cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.27347

Cite this

Serafini, M., Jakszyn, P., Luján-Barroso, L., Agudo, A., Bas Bueno-De-Mesquita, H., Van Duijnhoven, F. J. B., Jenab, M., Navarro, C., Palli, D., Boeing, H., Wallström, P., Regnér, S., Numans, M. E., Carneiro, F., Boutron-Ruault, M. C., Clavel-Chapelon, F., Morois, S., Grioni, S., Panico, S., ... González, C. A. (2012). Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. International Journal of Cancer, 131(4), E544-E554. https://doi.org/10.1002/ijc.27347

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title = "Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study",

abstract = "A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28-0.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.21-0.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.",

keywords = "antioxidant capacity, diet, longitudinal studies, stomach cancer",

author = "Mauro Serafini and Paula Jakszyn and Leila Luj{\'a}n-Barroso and Antonio Agudo and {Bas Bueno-De-Mesquita}, H. and {Van Duijnhoven}, {Fr{\"a}nzel J.B.} and Mazda Jenab and Carmen Navarro and Domenico Palli and Heiner Boeing and Peter Wallstr{\"o}m and Sara Regn{\'e}r and Numans, {Mattijs E.} and Fatima Carneiro and Boutron-Ruault, {Marie Christine} and Fran{\c c}oise Clavel-Chapelon and Sophie Morois and Sara Grioni and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and {Ramon Quir{\~o}s}, Jos{\'e} and Esther Molina-Montes and {Huerta Casta{\~n}o}, {Jose M.} and Aurelio Barricarte and Pilar Amiano and Khaw, {Kay Tee} and Nicholas Wareham and Allen, {Naomi E.} and Key, {Timothy J.} and Jeurnink, {Suzanne M.} and Peeters, {Petra H.M.} and Christina Bamia and Elisabeth Valanou and Antonia Trichopoulou and Rudolf Kaaks and Annekatrin Lukanova and Bergmann, {Manuela M.} and Bj{\"o}rn Lindkvist and Roger Stenling and Ingegerd Johansson and Dahm, {Christina C.} and Kim Overvad and Majken Jensen and Anja Olsen and Anne Tjonneland and Eiliv Lund and Sabina Rinaldi and Dominique Michaud and Traci Mouw and Elio Riboli and Gonz{\'a}lez, {Carlos A.}",

year = "2012",

month = aug,

day = "15",

doi = "10.1002/ijc.27347",

language = "English",

volume = "131",

pages = "E544--E554",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley-Liss Inc.",

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Serafini, M, Jakszyn, P, Luján-Barroso, L, Agudo, A, Bas Bueno-De-Mesquita, H, Van Duijnhoven, FJB, Jenab, M, Navarro, C, Palli, D, Boeing, H, Wallström, P, Regnér, S, Numans, ME, Carneiro, F, Boutron-Ruault, MC, Clavel-Chapelon, F, Morois, S, Grioni, S, Panico, S, Tumino, R, Sacerdote, C, Ramon Quirõs, J, Molina-Montes, E, Huerta Castaño, JM, Barricarte, A, Amiano, P, Khaw, KT, Wareham, N, Allen, NE, Key, TJ, Jeurnink, SM, Peeters, PHM, Bamia, C, Valanou, E, Trichopoulou, A, Kaaks, R, Lukanova, A, Bergmann, MM, Lindkvist, B, Stenling, R, Johansson, I, Dahm, CC, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Lund, E, Rinaldi, S, Michaud, D, Mouw, T, Riboli, E & González, CA 2012, 'Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study', International Journal of Cancer, vol. 131, no. 4, pp. E544-E554. https://doi.org/10.1002/ijc.27347

TY - JOUR

T1 - Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

AU - Serafini, Mauro

AU - Jakszyn, Paula

AU - Luján-Barroso, Leila

AU - Agudo, Antonio

AU - Bas Bueno-De-Mesquita, H.

AU - Van Duijnhoven, Fränzel J.B.

AU - Jenab, Mazda

AU - Navarro, Carmen

AU - Palli, Domenico

AU - Boeing, Heiner

AU - Wallström, Peter

AU - Regnér, Sara

AU - Numans, Mattijs E.

AU - Carneiro, Fatima

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Morois, Sophie

AU - Grioni, Sara

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Ramon Quirõs, José

AU - Molina-Montes, Esther

AU - Huerta Castaño, Jose M.

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Allen, Naomi E.

AU - Key, Timothy J.

AU - Jeurnink, Suzanne M.

AU - Peeters, Petra H.M.

AU - Bamia, Christina

AU - Valanou, Elisabeth

AU - Trichopoulou, Antonia

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Bergmann, Manuela M.

AU - Lindkvist, Björn

AU - Stenling, Roger

AU - Johansson, Ingegerd

AU - Dahm, Christina C.

AU - Overvad, Kim

AU - Jensen, Majken

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Lund, Eiliv

AU - Rinaldi, Sabina

AU - Michaud, Dominique

AU - Mouw, Traci

AU - Riboli, Elio

AU - González, Carlos A.

PY - 2012/8/15

Y1 - 2012/8/15

N2 - A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28-0.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.21-0.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.

AB - A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28-0.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.21-0.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.

KW - antioxidant capacity

KW - diet

KW - longitudinal studies

KW - stomach cancer

UR - http://www.scopus.com/inward/record.url?scp=84862544932&partnerID=8YFLogxK

U2 - 10.1002/ijc.27347

DO - 10.1002/ijc.27347

M3 - Article

C2 - 22072493

AN - SCOPUS:84862544932

SN - 0020-7136

VL - 131

SP - E544-E554

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Abstract

Keywords

UN SDGs

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