DEHYDROGENATION OF 5,6-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES: A CONVENIENT LAST STEP FOR A SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES

Irene Perez-Pi; Xavier Berzosa; Iñaki Galve; Jordi Teixido; Jose I. Borrell

doi:10.3987/COM-10-S(E)28

DEHYDROGENATION OF 5,6-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES: A CONVENIENT LAST STEP FOR A SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES

Irene Perez-Pi
, Xavier Berzosa
, Iñaki Galve
, Jordi Teixido
, Jose I. Borrell^*

^*Corresponding author for this work

IQS School of Engineering

Research output: Indexed journal article › Article › peer-review

9 Citations (Web of Science)

Abstract

Two new protocols for the dehydrogenation of 5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones to pyrido[2,3-d]pyrimidin-7(8H)-ones are described. The first one uses NaH in DMSO an affords the corresponding pyridopyrimidines when an aryl substituent is present at C6. The second one is of a more general use, allowing dehydrogenation of aryl and alkyl substituted 5,6-dihydropyridopyrimdines upon treatment with Na2SeO3 in DMSO.

Original language	English
Pages (from-to)	581-591
Number of pages	11
Journal	Heterocycles
Volume	82
Issue number	1
DOIs	https://doi.org/10.3987/COM-10-S(E)28
Publication status	Published - 31 Dec 2010

Keywords

5,6-Dihydropyrido[2,3-d]pyrimidin-7(8H)-one
Dehydrogenation
Pyrido[2,3-d]pyrimidin-7(8h)-one
Sodium Hydride
Sodium Selenite

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title = "DEHYDROGENATION OF 5,6-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES: A CONVENIENT LAST STEP FOR A SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES",

abstract = "Two new protocols for the dehydrogenation of 5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones to pyrido[2,3-d]pyrimidin-7(8H)-ones are described. The first one uses NaH in DMSO an affords the corresponding pyridopyrimidines when an aryl substituent is present at C6. The second one is of a more general use, allowing dehydrogenation of aryl and alkyl substituted 5,6-dihydropyridopyrimdines upon treatment with Na2SeO3 in DMSO.",

keywords = "5,6-Dihydropyrido[2,3-d]pyrimidin-7(8H)-one, Dehydrogenation, Pyrido[2,3-d]pyrimidin-7(8h)-one, Sodium Hydride, Sodium Selenite",

author = "Irene Perez-Pi and Xavier Berzosa and I{\~n}aki Galve and Jordi Teixido and Borrell, \{Jose I.\}",

year = "2010",

month = dec,

day = "31",

doi = "10.3987/COM-10-S(E)28",

language = "English",

volume = "82",

pages = "581--591",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

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TY - JOUR

T1 - DEHYDROGENATION OF 5,6-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES

T2 - A CONVENIENT LAST STEP FOR A SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES

AU - Perez-Pi, Irene

AU - Berzosa, Xavier

AU - Galve, Iñaki

AU - Teixido, Jordi

AU - Borrell, Jose I.

PY - 2010/12/31

Y1 - 2010/12/31

N2 - Two new protocols for the dehydrogenation of 5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones to pyrido[2,3-d]pyrimidin-7(8H)-ones are described. The first one uses NaH in DMSO an affords the corresponding pyridopyrimidines when an aryl substituent is present at C6. The second one is of a more general use, allowing dehydrogenation of aryl and alkyl substituted 5,6-dihydropyridopyrimdines upon treatment with Na2SeO3 in DMSO.

AB - Two new protocols for the dehydrogenation of 5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones to pyrido[2,3-d]pyrimidin-7(8H)-ones are described. The first one uses NaH in DMSO an affords the corresponding pyridopyrimidines when an aryl substituent is present at C6. The second one is of a more general use, allowing dehydrogenation of aryl and alkyl substituted 5,6-dihydropyridopyrimdines upon treatment with Na2SeO3 in DMSO.

KW - 5,6-Dihydropyrido[2,3-d]pyrimidin-7(8H)-one

KW - Dehydrogenation

KW - Pyrido[2,3-d]pyrimidin-7(8h)-one

KW - Sodium Hydride

KW - Sodium Selenite

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000286906100038&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.3987/COM-10-S(E)28

DO - 10.3987/COM-10-S(E)28

M3 - Article

SN - 0385-5414

VL - 82

SP - 581

EP - 591

JO - Heterocycles

JF - Heterocycles

IS - 1

ER -

DEHYDROGENATION OF 5,6-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES: A CONVENIENT LAST STEP FOR A SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES

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