Comorbidity between bipolar disorder and borderline personality disorder: Prevalence, explanatory theories, and clinical impact

Álvaro Frías, Itziar Baltasar, Boris Birmaher

Research output: Indexed journal article Reviewpeer-review

56 Citations (Scopus)

Abstract

Background The relationship between bipolar disorder (BD) and borderline personality disorder (BPD) has been controversial and widely debated. Specifically, the comorbidity between both disorders has yielded a plethora of research, but there are no comprehensive reviews on this issue. Objective To determine the empirical evidence regarding the comorbidity between BD and BPD based on prevalence data, explanatory theories for their co-occurrence, and clinical impact of one disorder in the other. Method A comprehensive search of databases (PubMed and PsycINFO) was performed. Published manuscripts between January 1985 and August 2015 were identified. Overall, 70 studies fulfilled inclusion criteria. Results Over a fifth of subjects showed comorbidity between BPD and BD. Empirical evidence from common underlying factors was inconclusive, but BPD appears to be a risk factor for BD. Data also indicated that the negative impact of BPD in BD (e.g., suicidality, worse mood course) was greater than vice verse. Conclusions Given the high prevalence of comorbidity between BD and BPD and the negative effects of BPD in subjects with BD, further studies are needed to clarify the factor associated with the comorbidity between these two disorders. This information is important to develop appropriate treatments for subjects with both disorders, improve their clinical course, and prevent the increased risk of suicidality commonly found in these subjects.

Original languageEnglish
Pages (from-to)210-219
Number of pages10
JournalJournal of Affective Disorders
Volume202
DOIs
Publication statusPublished - 15 Sept 2016
Externally publishedYes

Keywords

  • Bipolar disorder
  • Borderline personality disorder
  • Comorbidity

Fingerprint

Dive into the research topics of 'Comorbidity between bipolar disorder and borderline personality disorder: Prevalence, explanatory theories, and clinical impact'. Together they form a unique fingerprint.

Cite this