TY - JOUR
T1 - Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
AU - Michaud, Dominique S.
AU - Gallo, Valentina
AU - Schlehofer, Brigitte
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Dahm, Christina C.
AU - Teucher, Birgit
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Schütze, Madlen
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Kyrozis, Andreas
AU - Sacerdote, Carlotta
AU - Krogh, Vittorio
AU - Masala, Giovanna
AU - Tumino, Rosario
AU - Mattiello, Amalia
AU - Bueno-de-Mesquita, H. Bas
AU - Ros, Martine M.
AU - Peeters, Petra H.M.
AU - Van Gils, Carla H.
AU - Skeie, Guri
AU - Engeset, Dagrun
AU - Parr, Christine L.
AU - Ardanaz, Eva
AU - Chirlaque, Maria Dolores
AU - Dorronsoro, Miren
AU - Sánchez, Maria José
AU - Argüelles, Marcial
AU - Jakszyn, Paula
AU - Nilsson, Lena M.
AU - Melin, Beatrice S.
AU - Manjer, Jonas
AU - Wirfält, Elisabet
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Allen, Naomi E.
AU - Key, Timothy J.
AU - Romieu, Isabelle
AU - Vineis, Paolo
AU - Riboli, Elio
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Background: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. Objective: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. Results: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming ≥100 mL coffee and tea per day compared with those consuming <100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. Conclusions: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.
AB - Background: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. Objective: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. Results: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming ≥100 mL coffee and tea per day compared with those consuming <100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. Conclusions: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.
UR - http://www.scopus.com/inward/record.url?scp=78149257704&partnerID=8YFLogxK
U2 - 10.3945/ajcn.2010.29876
DO - 10.3945/ajcn.2010.29876
M3 - Article
C2 - 20844074
AN - SCOPUS:78149257704
SN - 0002-9165
VL - 92
SP - 1145
EP - 1150
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -
