Chlorotrimethylsilane: A suitable reagent for the synthesis of chlorohydrin esters

Jordi Eras, Jonh Jairo Méndez, Mercé Balcells, Ramon Canela

Research output: Indexed journal article Articlepeer-review

24 Citations (Scopus)


A new methodology for obtaining chlorohydrin esters using a one-pot esterification-chlorination reaction, in which one of the reagents, chlorotrimethylsilane, acts as solvent, is described. The reaction is stereospecific and its regioselectivity depends on the number of carbons between the hydroxyl groups present in the starting material. A mechanism is proposed.

Original languageEnglish
Pages (from-to)8631-8634
Number of pages4
JournalJournal of Organic Chemistry
Issue number24
Publication statusPublished - 29 Nov 2002
Externally publishedYes


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