Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

Rubén Ruiz-González; Francesca Setaro; Òscar Gulías; Montserrat Agut; Uwe Hahn; Tomás Torres; Santi Nonell

doi:10.1039/c7ob02270k

Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

Rubén Ruiz-González, Francesca Setaro, Òscar Gulías, Montserrat Agut, Uwe Hahn^*, Tomás Torres, Santi Nonell

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

25 Citations (Scopus)

Abstract

In the present study we describe the synthesis, photophysical properties and the photoinactivation performance against representative microorganisms of two families of cationic dendrimeric phthalocyanines as potential photosensitisers. Four charged dendrimeric compounds varying in their degree of ionicity (4 or 8 positive charges) and the coordinating metal (zinc or ruthenium) are compared and assessed as potential photosensitising agents in terms of their antimicrobial activity.

Original language	English
Pages (from-to)	9008-9017
Number of pages	10
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	42
Early online date	18 Oct 2017
DOIs	https://doi.org/10.1039/c7ob02270k
Publication status	Published - 14 Nov 2017

Keywords

Photophysical properties
Efficient photosensitizers
Photodynamic inactivation
Antibiotics
Porphyrins
Resistance
Therapy
Photoinactivation
Porphycenes
Infections

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abstract = "In the present study we describe the synthesis, photophysical properties and the photoinactivation performance against representative microorganisms of two families of cationic dendrimeric phthalocyanines as potential photosensitisers. Four charged dendrimeric compounds varying in their degree of ionicity (4 or 8 positive charges) and the coordinating metal (zinc or ruthenium) are compared and assessed as potential photosensitising agents in terms of their antimicrobial activity.",

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AU - Ruiz-González, Rubén

AU - Setaro, Francesca

AU - Gulías, Òscar

AU - Agut, Montserrat

AU - Hahn, Uwe

AU - Torres, Tomás

AU - Nonell, Santi

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KW - Efficient photosensitizers

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KW - Resistance

KW - Therapy

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KW - Porphycenes

KW - Infections

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Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

Abstract

Keywords

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