Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus

Enrique Almanza-Aguilera, Álvaro Hernáez, Dolores Corella, Albert Sanllorente, Emilio Ros, Olga Portolés, Julieta Valussi, Ramon Estruch, Oscar Coltell, Isaac Subirana, Silvia Canudas, Cristina Razquin, Gemma Blanchart, Lara Nonell, Montserrat Fitó, Olga Castañer

Research output: Indexed journal article Articlepeer-review

2 Citations (Scopus)

Abstract

We aimed to explore the differences in the whole transcriptome of peripheral blood mononu-clear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological func-tions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini–Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant “upregulation” and ≤−2.0 “downregulation”). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, −log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, −log(p-value) = 2.03) and paxillin (z-score = 2.33, −log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation in-hibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = −2.14, −log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.

Original languageEnglish
Article number85
Pages (from-to)1-12
Number of pages12
JournalJournal of clinical medicine
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Cancer
  • Microarray
  • Signaling pathways
  • Transcriptome
  • Type 2 diabetes

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