BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Maria C. Lucana; Fabien Gosselet; Cristina Díaz-Perlas; Benjamí Oller-Salvia; Roberta  Lucchi

doi:10.1039/d3cb00194f

BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Maria C. Lucana
, Fabien Gosselet
, Cristina Díaz-Perlas^*
, Benjamí Oller-Salvia^*
, Roberta Lucchi

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

12 Citations (Scopus)

Abstract

Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	RSC Chemical Biology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1039/d3cb00194f
Publication status	Published - Jan 2024

Keywords

Shuttle peptides
Barrier
Antibodies
Selection

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10.1039/d3cb00194fLicence: CC BY

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abstract = "Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.",

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author = "Lucana, \{Maria C.\} and Fabien Gosselet and Cristina D{\'i}az-Perlas and Benjam{\'i} Oller-Salvia and Roberta Lucchi",

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AU - Lucana, Maria C.

AU - Gosselet, Fabien

AU - Díaz-Perlas, Cristina

AU - Oller-Salvia, Benjamí

AU - Lucchi, Roberta

PY - 2024/1

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AB - Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.

KW - Shuttle peptides

KW - Barrier

KW - Antibodies

KW - Selection

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BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Abstract

Keywords

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