TY - JOUR
T1 - Brain energy metabolism
T2 - A roadmap for future research
AU - Rae, Caroline D.
AU - Baur, Joseph A.
AU - Borges, Karin
AU - Dienel, Gerald
AU - Díaz-García, Carlos Manlio
AU - Douglass, Starlette R.
AU - Drew, Kelly
AU - Duarte, João M N
AU - Duran, Jordi
AU - Kann, Oliver
AU - Kristian, Tibor
AU - Lee-Liu, Dasfne
AU - Lindquist, Britta E.
AU - McNay, Ewan C.
AU - Robinson, Michael B.
AU - Rothman, Douglas L.
AU - Rowlands, Benjamin D.
AU - Ryan, Timothy A.
AU - Scafidi, Joseph
AU - Scafidi, Susanna
AU - Shuttleworth, C. William
AU - Swanson, Raymond A.
AU - Uruk, Gökhan
AU - Vardjan, Nina
AU - Zorec, Robert
AU - McKenna, Mary C.
N1 - Publisher Copyright:
© 2024 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
PY - 2024/5
Y1 - 2024/5
N2 - Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research.
AB - Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research.
KW - acetate
KW - aerobic glycolysis
KW - GLUT4
KW - insulin
KW - noradrenaline
UR - https://www.scopus.com/pages/publications/85181446669
UR - http://hdl.handle.net/20.500.14342/4906
U2 - 10.1111/jnc.16032
DO - 10.1111/jnc.16032
M3 - Article
AN - SCOPUS:85181446669
SN - 0022-3042
VL - 168
SP - 910
EP - 954
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 5
ER -