Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei

Josep Sauri; Mikhail Reibarkh; Ting Zhang; Ryan D. Cohen; Xiao Wang; Tadeusz F. Molinski; Gary E. Martin; R. Thomas Williamson

doi:10.1021/acs.orglett.6b02158

Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei

Josep Sauri, Mikhail Reibarkh, Ting Zhang, Ryan D. Cohen, Xiao Wang, Tadeusz F. Molinski, Gary E. Martin, R. Thomas Williamson

Research output: Indexed journal article › Article › peer-review

10 Citations (Scopus)

Abstract

A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.

Original language	English
Pages (from-to)	4786-4789
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	19
DOIs	https://doi.org/10.1021/acs.orglett.6b02158
Publication status	Published - 7 Oct 2016
Externally published	Yes

Keywords

Quantum coherence
Natural-products
Chemical-shifts
Assignment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.orglett.6b02158

Cite this

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title = "Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei",

abstract = "A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.",

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language = "English",

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T2 - A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei

AU - Sauri, Josep

AU - Reibarkh, Mikhail

AU - Zhang, Ting

AU - Cohen, Ryan D.

AU - Wang, Xiao

AU - Molinski, Tadeusz F.

AU - Martin, Gary E.

AU - Williamson, R. Thomas

PY - 2016/10/7

Y1 - 2016/10/7

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AB - A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.

KW - Quantum coherence

KW - Natural-products

KW - Chemical-shifts

KW - Assignment

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Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of <SUP>35,37</SUP>Cl Isotope Effects for <SUP>13</SUP>C Nuclei

Abstract

Keywords

UN SDGs

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