Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

Iolanda Jordan; Patricia Corniero; Mònica Balaguer; Jessica Ortiz; David Vila; Jesús Velasco; Francisco J. Cambra; Elisabeth Esteban

doi:10.2217/BMM.14.77

Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

Iolanda Jordan, Patricia Corniero, Mònica Balaguer, Jessica Ortiz, David Vila, Jesús Velasco, Francisco J. Cambra, Elisabeth Esteban

Research output: Indexed journal article › Article › peer-review

16 Citations (Scopus)

Abstract

Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

Original language	English
Pages (from-to)	1065-1072
Number of pages	8
Journal	Biomarkers in Medicine
Volume	8
Issue number	9
DOIs	https://doi.org/10.2217/BMM.14.77
Publication status	Published - 1 Oct 2014
Externally published	Yes

Keywords

Adrenomedullin
C-reactive protein
Diagnostic
Procalcitonin
Sepsis

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10.2217/BMM.14.77

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title = "Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children",

abstract = "Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.",

keywords = "Adrenomedullin, C-reactive protein, Diagnostic, Procalcitonin, Sepsis",

author = "Iolanda Jordan and Patricia Corniero and M{\`o}nica Balaguer and Jessica Ortiz and David Vila and Jes{\'u}s Velasco and Cambra, {Francisco J.} and Elisabeth Esteban",

note = "Publisher Copyright: {\textcopyright} 2014 Future Medicine Ltd.",

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doi = "10.2217/BMM.14.77",

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T1 - Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

AU - Jordan, Iolanda

AU - Corniero, Patricia

AU - Balaguer, Mònica

AU - Ortiz, Jessica

AU - Vila, David

AU - Velasco, Jesús

AU - Cambra, Francisco J.

AU - Esteban, Elisabeth

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

AB - Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

KW - Adrenomedullin

KW - C-reactive protein

KW - Diagnostic

KW - Procalcitonin

KW - Sepsis

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SN - 1752-0363

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EP - 1072

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

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ER -

Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

Abstract

Keywords

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