A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Oriol Planas; Thibault Gallavardin; Santi Nonell

doi:10.1039/c4cc09070e

A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Oriol Planas, Thibault Gallavardin, Santi Nonell

Research output: Indexed journal article › Article › peer-review

32 Citations (Web of Science)

Abstract

Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.

Original language	English
Pages (from-to)	5586-5589
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	26
DOIs	https://doi.org/10.1039/c4cc09070e
Publication status	Published - 4 Apr 2015

Keywords

Photodynamic therapy
Photophysical properties
Probe-design
Live-cell
Porphycene
Fluorescence
2-aminobenzothiazoles
Photosensitizer
Derivatives
Cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c4cc09070e

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AU - Planas, Oriol

AU - Gallavardin, Thibault

AU - Nonell, Santi

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/4/4

Y1 - 2015/4/4

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KW - Photophysical properties

KW - Probe-design

KW - Live-cell

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KW - Fluorescence

KW - 2-aminobenzothiazoles

KW - Photosensitizer

KW - Derivatives

KW - Cancer

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A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Abstract

Keywords

UN SDGs

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