A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González; John H. White; Montserrat Agut; Santi Nonell; Cristina Flors

doi:10.1039/c2pp25126d

A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González, John H. White, Montserrat Agut, Santi Nonell^*, Cristina Flors

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

23 Citations (Scopus)

Abstract

TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

Original language	English
Pages (from-to)	1411-1413
Number of pages	3
Journal	Photochemical and Photobiological Sciences
Volume	11
Issue number	9
DOIs	https://doi.org/10.1039/c2pp25126d
Publication status	Published - Sept 2012

Keywords

Photodynamic therapy
Escherichia-coli
Inactivation
Light

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abstract = "TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.",

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AU - Agut, Montserrat

AU - Nonell, Santi

AU - Flors, Cristina

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KW - Escherichia-coli

KW - Inactivation

KW - Light

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A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Abstract

Keywords

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