A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González, John H. White, Montserrat Agut, Santi Nonell, Cristina Flors

Research output: Indexed journal article Articlepeer-review

22 Citations (Scopus)

Abstract

TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

Original languageEnglish
Pages (from-to)1411-1413
Number of pages3
JournalPhotochemical and Photobiological Sciences
Volume11
Issue number9
DOIs
Publication statusPublished - Sept 2012

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