A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

Jordi Martorell López; Mercedes Balcells Camps; Gemma Molins Gutiérrez; Antonio Gabino Salazar Gabino

doi:10.1007/978-1-0716-2289-6_10

A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

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Abstract

The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.

Translated title of the contribution	A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress
Original language	English
Title of host publication	The Blood-Brain Barrier
Publisher	Springer Nature
Pages	175-190
Number of pages	0
Volume	2492
ISBN (Print)	978-1-0716-2289-6
DOIs	https://doi.org/10.1007/978-1-0716-2289-6_10
Publication status	Published - 1 Jun 2022

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title = "A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress",

abstract = "The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.",

author = "\{Martorell L{\'o}pez\}, Jordi and \{Balcells Camps\}, Mercedes and \{Molins Guti{\'e}rrez\}, Gemma and \{Salazar Gabino\}, \{Antonio Gabino\}",

note = "This work was supported in part by a grant from Spain Ministerio de Econom{\'i}a y Competitividad (SAF-2017-84773-C2, MB) and by the Global CoCreation Lab (GM, MB).",

year = "2022",

month = jun,

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doi = "10.1007/978-1-0716-2289-6\_10",

language = "English",

isbn = "978-1-0716-2289-6",

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TY - CHAP

T1 - A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

AU - Martorell López, Jordi

AU - Balcells Camps, Mercedes

AU - Molins Gutiérrez, Gemma

AU - Salazar Gabino, Antonio Gabino

N1 - This work was supported in part by a grant from Spain Ministerio de Economía y Competitividad (SAF-2017-84773-C2, MB) and by the Global CoCreation Lab (GM, MB).

PY - 2022/6/1

Y1 - 2022/6/1

N2 - The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.

AB - The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.

UR - https://www.scopus.com/pages/publications/85132620426

U2 - 10.1007/978-1-0716-2289-6_10

DO - 10.1007/978-1-0716-2289-6_10

M3 - Chapter

C2 - 35733045

SN - 978-1-0716-2289-6

VL - 2492

SP - 175

EP - 190

BT - The Blood-Brain Barrier

PB - Springer Nature

ER -

A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

Abstract

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