A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein

Beatriz Rodríguez-Amigo, Cormac Hally, Núria Roig-Yanovsky, Pietro Delcanale, Stefania Abbruzzetti, Montserrat Agut, Cristiano Viappiani, Santi Nonell

Research output: Indexed journal article Articlepeer-review

4 Citations (Scopus)

Abstract

Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β-lactoglobulin as a double payload carrier of hypericin (an antimicrobial photodynamic agent) and all-trans retinoic acid (an anti-inflammatory drug) for S. aureus in vitro photodynamic inactivation. The addition of all-trans retinoic acid to hypericinβ-lactoglobulin complex renders a photochemically safe vehicle due to the photophysical quenching of hypericin, which recovers its photodynamic activity when in contact with bacteria. The ability of hypericin to photoinactivate S. aureus was not affected by retinoic acid. β-Lactoglobulin is a novel biocompatible and photochemically safe nanovehicle with strong potential for the treatment of acne.

Original languageEnglish
Article number282
JournalAntibiotics
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Acne vulgaris
  • Hypericin
  • Photodynamic therapy
  • Retinoic acid
  • β-lactoglobulin

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