Abstract
The synthesis of dimethyl 2-(methoxymethylene) pentanedioates by an unusual Michael addition of 3,3-dimethoxypropionate to α, β-unsaturated esters is described. These new intermediates can subsequently be converted to methyl 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoates upon treatment with guanidine carbonate. The resulting pyrimidine derivatives are open-chain analogues of pyrido[2,3-d]pyrimidines with interesting biological activities.
Original language | English |
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Pages (from-to) | 595-601 |
Number of pages | 7 |
Journal | Molecular Diversity |
Volume | 15 |
Issue number | 2 |
DOIs | |
Publication status | Published - May 2011 |
Keywords
- Methyl 3,3-dimethoxypropionate
- Michael addition
- Microwave synthesis
- Pyrimidin-5-ylpropanoic acids
- α,β-Unsaturated ester