A diversity-oriented, microwave-assisted synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones

N. Mont, L. Fernández-Megido, J. Teixidó, C. O. Kappe, J. I. Borrell

Research output: Indexed journal article Articlepeer-review

14 Citations (Scopus)


A microwave-assisted protocol for the synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones, 13 and 9 respectively, bearing a carbon substituent at C2 and a chlorine atom at C4 is reported. The introduction of a wide range of substituents at C2 renders this methodology easily amenable to combinatorial chemistry applications. Two examples of further derivatization of compounds 9, substitution by amine and Suzuki coupling, under microwave irradiation are also described.

Original languageEnglish
Pages (from-to)836-849
Number of pages14
JournalQSAR and Combinatorial Science
Issue number10
Publication statusPublished - Dec 2004


  • Combinatorial Chemistry
  • Microwave assisted synthesis
  • Pyrido[2,3-d]pyrimidines
  • Suzuki coupling


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