TY - JOUR
T1 - A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Crowe, Francesca L.
AU - Key, Timothy J.
AU - Allen, Naomi E.
AU - Appleby, Paul N.
AU - Overvad, Kim
AU - Grønbæk, Henning
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Dossus, Laure
AU - Boeing, Heiner
AU - Kröger, Janine
AU - Trichopoulou, Antonia
AU - Zylis, Dimosthenis
AU - Trichopoulos, Dimitrios
AU - Boutron-Ruault, Marie Christine
AU - De Lauzon-Guillain, Blandine
AU - Clavel-Chapelon, Françoise
AU - Palli, Domenico
AU - Berrino, Franco
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Bueno-De-Mesquita, H. Bas
AU - Van Gils, Carla H.
AU - Peeters, Petra H.M.
AU - Gram, Inger T.
AU - Rodŕguez, Laudina
AU - Jakszyn, Paula
AU - Molina-Montes, Esther
AU - Navarro, Carmen
AU - Barricarte, Aurelio
AU - Larräaga, Nerea
AU - Khaw, Kay Tee
AU - Rodwell, Sheila
AU - Rinaldi, Sabina
AU - Slimani, Nadia
AU - Norat, Teresa
AU - Gallo, Valentina
AU - Riboli, Elio
AU - Kaaks, Rudolf
N1 - Funding Information:
Europe Against Cancer Program of the European Commission (SANCO); Danish Cancer Society; German Cancer Aid; Ligue Nationale contre le Cancer, 3M Company, INSERM; German Cancer Research Centre; German Federal Ministry of Education and Research; Dutch Ministry of Public Health, Welfare and Sports; National Cancer Registry and the Regional Cancer Registries Amsterdam, Dutch Ministry of Health; Dutch Prevention Funds; LK Research Funds; Dutch Zorg Onderzoek Nederland; East and Maastricht of The Netherlands; Norwegian Cancer Society; Norwegian Research Council; Health Research Fund (FIS) of the Spanish Ministry of Health; Hellenic Ministry of Health; Stavros Niarchos Foundation; Hellenic Health Foundation; Italian Association for Research on Cancer; Italian National Research Council; Spanish Regional Governments of Andalusia, Asturias, Basque Country, Murcia and Navarra and ISCIII, Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden; Cancer Research UK; Medical Research Council, UK; Stroke Association, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; Wellcome Trust, UK; the US Army Medical Research and Material Command (DAMD 17-01-0275); US National Cancer Institute (contract no. U01 CA098216-01) and World Cancer Research Fund. This research was conducted during tenure of a Girdlers’ New Zealand Health Research Council Fellowship.
PY - 2011/3
Y1 - 2011/3
N2 - Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m2 had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
AB - Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m2 had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
KW - Body height
KW - Body mass index
KW - Insulin-like growth factor I
KW - Insulin-like growth factor binding proteins
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=79551495819&partnerID=8YFLogxK
U2 - 10.3109/03014460.2010.507221
DO - 10.3109/03014460.2010.507221
M3 - Article
C2 - 20731527
AN - SCOPUS:79551495819
SN - 0301-4460
VL - 38
SP - 194
EP - 202
JO - Annals of Human Biology
JF - Annals of Human Biology
IS - 2
ER -
