2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds

Blanca Martínez-Teipel; Jordi Teixidó; Rosalia Pascual; Marta Mora; Josep Pujolà; Ted Fujimoto; José I. Borrell; Enrique L. Michelotti

doi:10.1021/cc049828y

2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds

Blanca Martínez-Teipel, Jordi Teixidó, Rosalia Pascual, Marta Mora, Josep Pujolà, Ted Fujimoto, José I. Borrell, Enrique L. Michelotti

Research output: Indexed journal article › Article › peer-review

24 Citations (Scopus)

Abstract

Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6- tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.

Original language	English
Pages (from-to)	436-448
Number of pages	13
Journal	Journal of Combinatorial Chemistry
Volume	7
Issue number	3
DOIs	https://doi.org/10.1021/cc049828y
Publication status	Published - May 2005

Keywords

Tyrosine kinase inhibitors
Hydrogen halides
Irreversible inhibitors
1,5-dinitrile systems
Antitumor agents
Cyclization
4-(phenylamino)quinazoline
Discovery

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10.1021/cc049828y

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Martínez-Teipel, B., Teixidó, J., Pascual, R., Mora, M., Pujolà, J., Fujimoto, T., Borrell, J. I., & Michelotti, E. L. (2005). 2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds. Journal of Combinatorial Chemistry, 7(3), 436-448. https://doi.org/10.1021/cc049828y

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title = "2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds",

abstract = "Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6- tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.",

keywords = "Tyrosine kinase inhibitors, Hydrogen halides, Irreversible inhibitors, 1,5-dinitrile systems, Antitumor agents, Cyclization, 4-(phenylamino)quinazoline, Discovery",

author = "Blanca Mart{\'i}nez-Teipel and Jordi Teixid{\'o} and Rosalia Pascual and Marta Mora and Josep Pujol{\`a} and Ted Fujimoto and Borrell, {Jos{\'e} I.} and Michelotti, {Enrique L.}",

year = "2005",

month = may,

doi = "10.1021/cc049828y",

language = "English",

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Martínez-Teipel, B, Teixidó, J, Pascual, R, Mora, M, Pujolà, J, Fujimoto, T, Borrell, JI & Michelotti, EL 2005, '2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds', Journal of Combinatorial Chemistry, vol. 7, no. 3, pp. 436-448. https://doi.org/10.1021/cc049828y

2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds. / Martínez-Teipel, Blanca; Teixidó, Jordi; Pascual, Rosalia et al.
In: Journal of Combinatorial Chemistry, Vol. 7, No. 3, 05.2005, p. 436-448.

Research output: Indexed journal article › Article › peer-review

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T1 - 2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles

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AU - Martínez-Teipel, Blanca

AU - Teixidó, Jordi

AU - Pascual, Rosalia

AU - Mora, Marta

AU - Pujolà, Josep

AU - Fujimoto, Ted

AU - Borrell, José I.

AU - Michelotti, Enrique L.

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KW - Hydrogen halides

KW - Irreversible inhibitors

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KW - 4-(phenylamino)quinazoline

KW - Discovery

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2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds

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