α-Arylation/Heteroarylation of Chiral α-Aminomethyltrifluoroborates by Synergistic Iridium Photoredox/Nickel Cross-Coupling Catalysis

Mirna El Khatib; Ricardo Augusto Massarico Serafim; Gary A. Molander

doi:10.1002/anie.201506147

α-Arylation/Heteroarylation of Chiral α-Aminomethyltrifluoroborates by Synergistic Iridium Photoredox/Nickel Cross-Coupling Catalysis

Mirna El Khatib
, Ricardo Augusto Massarico Serafim
, Gary A. Molander

Research output: Indexed journal article › Article › peer-review

140 Citations (Scopus)

Abstract

Direct access to complex, enantiopure benzylamine architectures using a synergistic iridium photoredox/nickel cross-coupling dual catalysis strategy has been developed. New C(sp(3)) C(sp(2)) bonds are forged starting from abundant and inexpensive natural amino acids.

Original language	English
Pages (from-to)	254-258
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/anie.201506147
Publication status	Published - 4 Jan 2016
Externally published	Yes

Keywords

Amino acids
Cross-coupling
Heterocycles
Nickel
Photochemistry

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10.1002/anie.201506147

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abstract = "Direct access to complex, enantiopure benzylamine architectures using a synergistic iridium photoredox/nickel cross-coupling dual catalysis strategy has been developed. New C(sp(3)) C(sp(2)) bonds are forged starting from abundant and inexpensive natural amino acids.",

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AU - Molander, Gary A.

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KW - Nickel

KW - Photochemistry

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α-Arylation/Heteroarylation of Chiral α-Aminomethyltrifluoroborates by Synergistic Iridium Photoredox/Nickel Cross-Coupling Catalysis

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Keywords

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