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Collaborations and top research areas from the last five years
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EXODUS-BCL: Design and synthesis of novel dual-targeted IRAK4/BTK protein degraders to enhance therapeutic efficacy in aggressive B-cell lymphoma.
Estrada Tejedor, R. (PI), Borrell, J. I. (Researcher), Teixidó Closa, J. (Researcher), Gibert Bosch, A. (Researcher), Cuartero Albesa, A. M. (Researcher) & Puig De La Bellacasa Cazorla, R. (Researcher)
Agencia Estatal de Investigación
1/09/25 → 31/08/28
Project: Research Grants › Research
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CovDegSLKSTK10: Design and synthesis of covalent inhibitors and protacs for the protein kinases slk/stk10
Massarico Serafim, R. A. (PI), Estrada Tejedor, R. (Researcher), Elkins, J. (Collaborator), Romo, M. (Researcher) & Brunet Mesía, E. (Researcher)
1/01/25 → 31/12/25
Project: Internal grants/own calls › Internal Projects Grants
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PreClinIQS080: Estudio Preclínico Inicial de IQS080, un candidato a fármaco contra el cáncer de páncreas.
Borrell, J. I. (PI), Semino, C. E. (PI), Teixidó Closa, J. (Researcher), Estrada Tejedor, R. (Researcher), Puig De La Bellacasa Cazorla, R. (Researcher), Batllori Aguilà, X. (Researcher) & Villanueva Garatachea, A. (PI)
1/12/22 → 30/11/24
Project: Research Grants › Research
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DisX4lymph: Design and synthesis of CXCR4 allosteric inhibitors and IRAK4 degraders as potential treatments of B-cell lymphoma.
Estrada Tejedor, R. (PI), Borrell, J. I. (PI), Teixidó Closa, J. (Researcher), Gibert Bosch, A. (Researcher), Puig De La Bellacasa Cazorla, R. (Researcher) & Batllori Aguilà, X. (Researcher)
Agencia Estatal de Investigación
1/09/22 → 31/08/25
Project: Research Grants › Research
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GQF: Grup de Química Farmacèutica
Estrada Tejedor, R. (PI), Artalejo Ortega, B. (Researcher), Balfagón Costa, A. (Researcher), Batllori Aguilà, X. (Researcher), Borrell, J. I. (Researcher), Cuartero Albesa, A. M. (Researcher), Gibert Bosch, A. (Researcher), Lloveras Monserrat, M. (Researcher), Manén Freixa, L. (Researcher), Mercadé Prieto, R. (Researcher), Nomen Ribé, R. (Researcher), Puig De La Bellacasa Cazorla, R. (Researcher), Semino, C. E. (Researcher), Sempere Cebrian, J. (Researcher), Serra Hosta, E. (Researcher), Teixidó Closa, J. (Researcher), Torres Urtizberea, E. (Researcher), Arias Donaire, A. (Researcher), Gorjon-de-Pablo, G. (Researcher), Martínez-Asensio, M. (Researcher), Camaló Vila, J. (Researcher), Fernández-Remacha, D. (Researcher) & Massarico Serafim, R. A. (PI)
Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)
1/01/22 → 30/06/25
Project: Research Groups and Network Grants › Research Groups
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Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Boni, J., Fernández-González, M., Han, H. R., Roca, C., Wong, C. J., Rioja, C., Nogué, C., Manen-Freixa, L., Boulais, J., Torres-Urtizberea, E., Gomez, A., Hasselblatt, M., Estrada-Tejedor, R., Antolin, A. A., Elkholi, I. E., Jabado, N., Côté, J. F., Gingras, A. C. & Rivera, B., 15 Dec 2025, In: EMBO Journal. 44, 24, p. 7513-7540 28 p.Research output: Indexed journal article › Article › peer-review
Open Access -
Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect
de Pablo, G. G., Profitos-Peleja, N., Jacobs, M., Gonzalez-Herrero, A., Parra, J., Mereu, E., Cifuentes, P., Orphali, M., Teixidó Closa, J., Esteller, M., Borrell, J. I., Estrada-Tejedor, R. & Roue, G., 15 Apr 2025, In: Cancer Research. 85, 8, 2 p.Research output: Indexed journal article › Meeting Abstract › peer-review
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Discovery of novel CXCR4 targeting compounds with antitumor activity in preclinical models of diffuse large B-cell lymphoma
Fernandez-Serrano, M., Profitos-Peleja, N., Camalo-Vila, J., Martinez-Asensio, M., Teixido, J., Borrell, J. I., Gibert, A., de la Bellacasa, R. P., Estrada-Tejedor, R. & Roue, G., 15 Apr 2025, In: Cancer Research. 85, 8Research output: Indexed journal article › Meeting Abstract › peer-review
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Rational Method for Structural Simplification as Key Step in Hit Discovery: The Case of FGFR2 and IGF1R Dual Inhibitors
Torres-Urtizberea, E., Borrell, J. I., Puig de la Bellacasa, R. & Estrada-Tejedor, R., May 2025, In: International Journal of Molecular Sciences. 26, 9, 16 p., 4457.Research output: Indexed journal article › Article › peer-review
Open Access -
Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity
Martínez-Asensio, M., Sàrrias, L., Gorjón-de-Pablo, G., Fernández-Serrano, M., Camaló-Vila, J., Gibert, A., Puig de la Bellacasa, R., Teixidó, J., Roué, G., Borrell, J. I. & Estrada-Tejedor, R., Sept 2024, In: International Journal of Molecular Sciences. 25, 17, 14 p., 9446.Research output: Indexed journal article › Article › peer-review
Open Access