Ricardo Augusto Massarico Serafim

Emailricardo.serafimiqs.urledu

Brazil

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CovDegSLKSTK10: Design and synthesis of covalent inhibitors and protacs for the protein kinases slk/stk10
Massarico Serafim, R. A. (PI), Estrada Tejedor, R. (Researcher), Elkins, J. (Collaborator), Romo, M. (Researcher) & Brunet Mesía, E. (Researcher)
1/01/25 → 31/12/25
Project: Internal grants/own calls › Internal Projects Grants
GQF: Grup de Química Farmacèutica
Estrada Tejedor, R. (PI), Artalejo Ortega, B. (Researcher), Balfagón Costa, A. (Researcher), Batllori Aguilà, X. (Researcher), Borrell, J. I. (Researcher), Cuartero Albesa, A. M. (Researcher), Gibert Bosch, A. (Researcher), Lloveras Monserrat, M. (Researcher), Manén Freixa, L. (Researcher), Mercadé Prieto, R. (Researcher), Nomen Ribé, R. (Researcher), Puig De La Bellacasa Cazorla, R. (Researcher), Semino, C. E. (Researcher), Sempere Cebrian, J. (Researcher), Serra Hosta, E. (Researcher), Teixidó Closa, J. (Researcher), Torres Urtizberea, E. (Researcher), Arias Donaire, A. (Researcher), Gorjon-de-Pablo, G. (Researcher), Martínez-Asensio, M. (Researcher), Camaló Vila, J. (Researcher), Fernández-Remacha, D. (Researcher) & Massarico Serafim, R. A. (PI)
Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)
1/01/22 → 30/06/25
Project: Research Groups and Network Grants › Research Groups

18 Article
5 Review
2 Meeting Abstract
1 Editorial

Design, Synthesis, and Molecular Evaluation of S_NAr-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode
Ernst, L. N., Stahlecker, J., Mier, F., Serafim, R. A. M., Wydra, V. R., Masberg, B., Jaag, S. J., Knappe, C., Lämmerhofer, M., Stehle, T., Gehringer, M. & Boeckler, F. M., 10 Aug 2025, In: Archiv der Pharmazie. 358, 8, 22 p., e70053.
Research output: Indexed journal article › Article › peer-review

Open Access
Go for Gold: Development of a Scalable Synthesis of [1-(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors
Rebhan, L., Fuerst, R., Schollmeyer, D., Serafim, R. A. M. & Gehringer, M., Sept 2025, In: ChemistryOpen. 14, 9, 8 p., e202500106.
Research output: Indexed journal article › Article › peer-review

Open Access
High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024
Serafim, R. A. M. & Gehringer, M., 8 Aug 2025, In: ACS Pharmacology and Translational Science. 8, 8, p. 2401-2414 14 p.
Research output: Indexed journal article › Review › peer-review

Open Access
1 Citation (Scopus)
Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP
Ernst, L. N., Jaag, S. J., Wydra, V. R., Masberg, B., Knappe, C., Gerstenecker, S., Serafim, R. A. M., Liang, X. J., Seidler, N. J., Laemmerhofer, M., Gehringer, M. & Boeckler, F. M., 25 Mar 2025, In: Drug Design Development and Therapy. 19, p. 2253-2284 32 p.
Research output: Indexed journal article › Article › peer-review

Open Access
2 Citations (Scopus)
Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Ruscinc, N., Massarico Serafim, R. A., Almeida, C., Rosado, C. & Baby, A. R., 20 May 2024, In: Frontiers in Chemistry. 12, 11 p., 1400881.
Research output: Indexed journal article › Article › peer-review

Open Access
13 Citations (Scopus)

Ricardo Augusto Massarico Serafim

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Collaborations and top research areas from the last five years

Dive into details

CovDegSLKSTK10: Design and synthesis of covalent inhibitors and protacs for the protein kinases slk/stk10

GQF: Grup de Química Farmacèutica

Design, Synthesis, and Molecular Evaluation of S_NAr-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode

Go for Gold: Development of a Scalable Synthesis of [1-(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024

Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP

Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry

Ricardo Augusto Massarico Serafim

Personal profile

Fingerprint

Collaborations and top research areas from the last five years

Projects

CovDegSLKSTK10: Design and synthesis of covalent inhibitors and protacs for the protein kinases slk/stk10

GQF: Grup de Química Farmacèutica

Research output

Design, Synthesis, and Molecular Evaluation of SNAr-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode

Go for Gold: Development of a Scalable Synthesis of [1-(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024

Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP

Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry

Design, Synthesis, and Molecular Evaluation of S_NAr-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode