Zinc-Substituted Myoglobin Is a Naturally Occurring Photo-antimicrobial Agent with Potential Applications in Food Decontamination

Pietro Delcanale, Chiara Montali, Beatriz Rodríguez-Amigo, Stefania Abbruzzetti, Stefano Bruno, Paolo Bianchini, Alberto Diaspro, Montserrat Agut, Santi Nonell, Cristiano Viappiani

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Resum

Zinc-substituted myoglobin (ZnMb) is a naturally occurring photosensitizer that generates singlet oxygen with a high quantum yield. Using a combination of photophysical and fluorescence imaging techniques, we demonstrate the interaction of ZnMb with Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. An efficient antibacterial action against S. aureus was observed, with a reduction up to 99.9999% in the number of colony-forming units, whereas no sizable effect was detected against E. coli. Because ZnMb is known to form during the maturation of additive-free not-cooked cured ham, the use of this protein as a built-in photodynamic agent may constitute a viable method for the decontamination of these food products from Gram-positive bacteria.

Idioma originalAnglès
Pàgines (de-a)8633-8639
Nombre de pàgines7
RevistaJournal of Agricultural and Food Chemistry
Volum64
Número45
DOIs
Estat de la publicacióPublicada - 16 de nov. 2016

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