Ubiquitin and SUMO signalling in DNA repair

Timothy M. Thomson, Marta Guerra-Rebollo

Producció científica: Article en revista indexadaArticle de revisió (sistemàtica)Avaluat per experts

29 Cites (Scopus)


The repair of lesions and gaps in DNA follows different pathways, each mediated by specific proteins and complexes. Post-translational modifications in many of these proteins govern their activities and interactions, ultimately determining whether a particular pathway is followed. Prominent among these modifications are the addition of phosphate or ubiquitin (and ubiquitin-like) moieties that confer new binding surfaces and conformational states on the modified proteins. The present review summarizes some of consequences of ubiquitin and ubiquitin-like modifications and interactions that regulate nucleotide excision repair, translesion synthesis, double-strand break repair and interstrand cross-link repair, with the discussion of relevant examples in each pathway.

Idioma originalAnglès
Pàgines (de-a)116-131
Nombre de pàgines16
RevistaBiochemical Society Transactions
Estat de la publicacióPublicada - 2010
Publicat externament


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