Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Marta Marszalek; Antoni Planas; Teresa Pellicer

Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Marta Marszalek, Antoni Planas, Teresa Pellicer

Producció científica: Article en revista indexada › Article › Avaluat per experts

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many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

Idioma original	Anglès
Pàgines (de-a)	172-178
Nombre de pàgines	7
Revista	Afinidad
Volum	71
Número	567
Estat de la publicació	Publicada - 1 de jul. 2014

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abstract = "many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.",

keywords = "Drug targets, Latency, Tuberculosis, Two-component system",

author = "Marta Marszalek and Antoni Planas and Teresa Pellicer",

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AU - Marszalek, Marta

AU - Planas, Antoni

AU - Pellicer, Teresa

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Y1 - 2014/7/1

N2 - many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

AB - many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

KW - Drug targets

KW - Latency

KW - Tuberculosis

KW - Two-component system

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ER -

Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

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