Two-Component Coupling of Carbodiimides and Hydrazides Provides Convergent Access to Biologically Active Compounds

Elisabeth T. Hennessy; Maximilian D. Palkowitz; Josep Sauri; Aaron C. Sather

doi:10.1021/acs.orglett.2c02555

Two-Component Coupling of Carbodiimides and Hydrazides Provides Convergent Access to Biologically Active Compounds

Elisabeth T. Hennessy, Maximilian D. Palkowitz, Josep Sauri, Aaron C. Sather

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Resum

A novel, convergent synthesis of aminotriazoloquinazolines is reported. These heterocycles are reliably prepared via a "click-like " reaction between readily available aryl carbodiimides and acyl or aryl hydrazides. Such products are of particular interest with respect to their inhibitory activity against the A2A and A2B adenosine receptors, and the title two-component coupling reaction has greatly accelerated the discovery of potent/selective chemical matter in this space.

Idioma original	Anglès
Nombre de pàgines	4
Revista	Organic Letters
Data online anticipada	24 d’ag. 2022
DOIs	https://doi.org/10.1021/acs.orglett.2c02555
Estat de la publicació	Publicada - 2 de set. 2022
Publicat externament	Sí

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abstract = "A novel, convergent synthesis of aminotriazoloquinazolines is reported. These heterocycles are reliably prepared via a {"}click-like {"} reaction between readily available aryl carbodiimides and acyl or aryl hydrazides. Such products are of particular interest with respect to their inhibitory activity against the A2A and A2B adenosine receptors, and the title two-component coupling reaction has greatly accelerated the discovery of potent/selective chemical matter in this space.",

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author = "Hennessy, {Elisabeth T.} and Palkowitz, {Maximilian D.} and Josep Sauri and Sather, {Aaron C.}",

year = "2022",

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AU - Hennessy, Elisabeth T.

AU - Palkowitz, Maximilian D.

AU - Sauri, Josep

AU - Sather, Aaron C.

PY - 2022/9/2

Y1 - 2022/9/2

N2 - A novel, convergent synthesis of aminotriazoloquinazolines is reported. These heterocycles are reliably prepared via a "click-like " reaction between readily available aryl carbodiimides and acyl or aryl hydrazides. Such products are of particular interest with respect to their inhibitory activity against the A2A and A2B adenosine receptors, and the title two-component coupling reaction has greatly accelerated the discovery of potent/selective chemical matter in this space.

AB - A novel, convergent synthesis of aminotriazoloquinazolines is reported. These heterocycles are reliably prepared via a "click-like " reaction between readily available aryl carbodiimides and acyl or aryl hydrazides. Such products are of particular interest with respect to their inhibitory activity against the A2A and A2B adenosine receptors, and the title two-component coupling reaction has greatly accelerated the discovery of potent/selective chemical matter in this space.

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JF - Organic Letters

ER -

Two-Component Coupling of Carbodiimides and Hydrazides Provides Convergent Access to Biologically Active Compounds

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