TY - JOUR
T1 - Tuning of Ultrasmall Gold Nanoparticles Surface Properties Affect Their Biological Fate
AU - Ferreira, Avelino
AU - Fernandez Alarcon, Jennifer
AU - Guffanti, Federica
AU - Morelli, Annalisa
AU - Russo, Luca
AU - Violatto, Martina B.
AU - Cognet, Valentin
AU - Barrientos, Africa
AU - Soliman, Mahmoud G.
AU - Dobricic, Marko
AU - Moya, Sergio E.
AU - Bigini, Paolo
AU - Monopoli, Marco P.
N1 - Publisher Copyright:
© 2024 The Author(s). Particle & Particle Systems Characterization published by Wiley-VCH GmbH.
PY - 2024/11
Y1 - 2024/11
N2 - Ultrasmall nanoparticles of 10 nm or less in size have been shown to have great potential in the biomedical field due to their high surface area and strong tissue penetration. Their easy functionalization and unique behavior at the nanoscale, such as the reduced corona formation and lower liver retention allow them to be a potential tool for precision targeting. In this study, PEGylated ultrasmall gold nanoparticles (GNPs) with a 4 nm core size are developed. They are functionalized with the cyclic RGD (cRGD) targeting peptide, which provides high binding affinity toward αVβ3 integrin receptor, often overexpressed in solid tumors. Further evidence is presented that cRGD functionalized GNPs partially escape lysosomes while penetrating deeper into the liver parenchyma. These particles provide a potential future strategy for specific αVβ3 integrin targeting.
AB - Ultrasmall nanoparticles of 10 nm or less in size have been shown to have great potential in the biomedical field due to their high surface area and strong tissue penetration. Their easy functionalization and unique behavior at the nanoscale, such as the reduced corona formation and lower liver retention allow them to be a potential tool for precision targeting. In this study, PEGylated ultrasmall gold nanoparticles (GNPs) with a 4 nm core size are developed. They are functionalized with the cyclic RGD (cRGD) targeting peptide, which provides high binding affinity toward αVβ3 integrin receptor, often overexpressed in solid tumors. Further evidence is presented that cRGD functionalized GNPs partially escape lysosomes while penetrating deeper into the liver parenchyma. These particles provide a potential future strategy for specific αVβ3 integrin targeting.
KW - active targeting
KW - nanotechnology
KW - ultrasmall gold nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85195146683&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:001238990300001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1002/ppsc.202300168
DO - 10.1002/ppsc.202300168
M3 - Article
AN - SCOPUS:85195146683
SN - 0934-0866
VL - 41
JO - Particle and Particle Systems Characterization
JF - Particle and Particle Systems Characterization
IS - 11
M1 - 2300168
ER -