Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo

Mitchell J. Duffy, Oriol Planas, Andreas Faust, Thomas Vogl, Sven Hermann, Michael Schäfers, Santi Nonell, Cristian A. Strassert

Producció científica: Article en revista indexadaArticleAvaluat per experts

29 Cites (Scopus)

Resum

In this paper we establish a methodology to predict photoacoustic imaging capabilities from the structure of absorber molecules (sonochromes). The comparative in vitro and in vivo screening of naphthalocyanines and cyanine dyes has shown a substitution pattern dependent shift in photoacoustic excitation wavelength, with distal substitution producing the preferred maximum around 800 nm. Central ion change showed variable production of photoacoustic signals, as well as singlet oxygen photoproduction and fluorescence with the optimum for photoacoustic imaging being nickel(II). Our approach paves the way for the design, evaluation and realization of optimized sonochromes as photoacoustic contrast agents.

Idioma originalAnglès
Pàgines (de-a)49-61
Nombre de pàgines13
RevistaPhotoacoustics
Volum9
DOIs
Estat de la publicacióPublicada - de març 2018

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