TY - JOUR
T1 - The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro
AU - Spatz, Jordan M.
AU - Wein, Marc N.
AU - Gooi, Jonathan H.
AU - Qu, Yili
AU - Garr, Jenna L.
AU - Liu, Shawn
AU - Barry, Kevin J.
AU - Uda, Yuhei
AU - Lai, Forest
AU - Dedic, Christopher
AU - Balcells-Camps, Mercedes
AU - Kronenberg, Henry M.
AU - Babij, Philip
AU - Pajevic, Paola Divieti
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/7/3
Y1 - 2015/7/3
N2 - Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.
AB - Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.
UR - https://www.scopus.com/pages/publications/84936803678
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000357572800022&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1074/jbc.M114.628313
DO - 10.1074/jbc.M114.628313
M3 - Article
C2 - 25953900
AN - SCOPUS:84936803678
SN - 0021-9258
VL - 290
SP - 16744
EP - 16758
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 27
ER -