Resum
Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.
Idioma original | Anglès |
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Pàgines (de-a) | 16744-16758 |
Nombre de pàgines | 15 |
Revista | Journal of Biological Chemistry |
Volum | 290 |
Número | 27 |
DOIs | |
Estat de la publicació | Publicada - 3 de jul. 2015 |