The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

Jordan M. Spatz; Marc N. Wein; Jonathan H. Gooi; Yili Qu; Jenna L. Garr; Shawn Liu; Kevin J. Barry; Yuhei Uda; Forest Lai; Christopher Dedic; Mercedes Balcells-Camps; Henry M. Kronenberg; Philip Babij; Paola Divieti Pajevic

doi:10.1074/jbc.M114.628313

The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

Jordan M. Spatz, Marc N. Wein, Jonathan H. Gooi, Yili Qu, Jenna L. Garr, Shawn Liu, Kevin J. Barry, Yuhei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps, Henry M. Kronenberg, Philip Babij, Paola Divieti Pajevic

IQS School of Engineering

Producció científica: Article en revista indexada › Article › Avaluat per experts

209 Cites (Scopus)

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Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.

Idioma original	Anglès
Pàgines (de-a)	16744-16758
Nombre de pàgines	15
Revista	Journal of Biological Chemistry
Volum	290
Número	27
DOIs	https://doi.org/10.1074/jbc.M114.628313
Estat de la publicació	Publicada - 3 de jul. 2015

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10.1074/jbc.M114.628313

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Spatz, J. M., Wein, M. N., Gooi, J. H., Qu, Y., Garr, J. L., Liu, S., Barry, K. J., Uda, Y., Lai, F., Dedic, C., Balcells-Camps, M., Kronenberg, H. M., Babij, P., & Pajevic, P. D. (2015). The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro. Journal of Biological Chemistry, 290(27), 16744-16758. https://doi.org/10.1074/jbc.M114.628313

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title = "The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro",

abstract = "Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.",

author = "Spatz, {Jordan M.} and Wein, {Marc N.} and Gooi, {Jonathan H.} and Yili Qu and Garr, {Jenna L.} and Shawn Liu and Barry, {Kevin J.} and Yuhei Uda and Forest Lai and Christopher Dedic and Mercedes Balcells-Camps and Kronenberg, {Henry M.} and Philip Babij and Pajevic, {Paola Divieti}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

day = "3",

doi = "10.1074/jbc.M114.628313",

language = "English",

volume = "290",

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T1 - The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

AU - Spatz, Jordan M.

AU - Wein, Marc N.

AU - Gooi, Jonathan H.

AU - Qu, Yili

AU - Garr, Jenna L.

AU - Liu, Shawn

AU - Barry, Kevin J.

AU - Uda, Yuhei

AU - Lai, Forest

AU - Dedic, Christopher

AU - Balcells-Camps, Mercedes

AU - Kronenberg, Henry M.

AU - Babij, Philip

AU - Pajevic, Paola Divieti

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.

AB - Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.

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DO - 10.1074/jbc.M114.628313

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SN - 0021-9258

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EP - 16758

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

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