The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

Jordan M. Spatz, Marc N. Wein, Jonathan H. Gooi, Yili Qu, Jenna L. Garr, Shawn Liu, Kevin J. Barry, Yuhei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps, Henry M. Kronenberg, Philip Babij, Paola Divieti Pajevic

Producció científica: Article en revista indexadaArticleAvaluat per experts

223 Cites (Scopus)

Resum

Background: Recent studies have suggested osteocytes as key players in mechanosensation and skeletal metabolism. Results: Simulated microgravity induces an autonomous up-regulation of SOST/sclerostin and RANKL/OPG in a novel osteocytic cell line, Ocy454. Conclusion: Mechanical loading regulates intrinsic osteocyte responses in concert with hormonal and cytokine inputs. Significance: Learning how osteocytes sense mechanical loads would enable novel interventions to prevent disuse-induced bone loss.

Idioma originalAnglès
Pàgines (de-a)16744-16758
Nombre de pàgines15
RevistaJournal of Biological Chemistry
Volum290
Número27
DOIs
Estat de la publicacióPublicada - 3 de jul. 2015

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