Temocene: the porphycene analogue of temoporfin (Foscan®)

María García-Díaz; David Sánchez-García; Jorge Soriano; M. Lluïsa Sagristà; Margarita Mora; Ángeles Villanueva; Juan C. Stockert; Magdalena Cañete; Santi Nonell

doi:10.1039/c1md00065a

Temocene: the porphycene analogue of temoporfin (Foscan®)

María García-Díaz
, David Sánchez-García
, Jorge Soriano
, M. Lluïsa Sagristà
, Margarita Mora
, Ángeles Villanueva
, Juan C. Stockert
, Magdalena Cañete
, Santi Nonell^*

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

34 Cites (Scopus)

Resum

Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.

Idioma original	Anglès
Pàgines (de-a)	616-619
Nombre de pàgines	4
Revista	MedChemComm
Volum	2
Número	7
DOIs	https://doi.org/10.1039/c1md00065a
Estat de la publicació	Publicada - de jul. 2011

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10.1039/c1md00065a

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abstract = "Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.",

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month = jul,

doi = "10.1039/c1md00065a",

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T2 - the porphycene analogue of temoporfin (Foscan®)

AU - García-Díaz, María

AU - Sánchez-García, David

AU - Soriano, Jorge

AU - Sagristà, M. Lluïsa

AU - Mora, Margarita

AU - Villanueva, Ángeles

AU - Stockert, Juan C.

AU - Cañete, Magdalena

AU - Nonell, Santi

N1 - This content is free to download. © The Royal Society of Chemistry 2011

PY - 2011/7

Y1 - 2011/7

N2 - Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.

AB - Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.

KW - Photodynamic therapy

KW - Photosensitizers

KW - Tetraphenylporphycene

KW - Apoptosis

KW - Porphyrin

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JO - MedChemComm

JF - MedChemComm

IS - 7

ER -

Temocene: the porphycene analogue of temoporfin (Foscan®)

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