TY - JOUR
T1 - Synthesis of 2,7,12,17-tetraphenylporphycene (TPPo). First aryl-substituted porphycene for the photodynamic therapy of tumors
AU - Nonell, Santiago
AU - Bou, Núria
AU - Borrell, JoséI I.
AU - Teixidó, Jordi
AU - Villanueva, Angeles
AU - Juarranz, Angeles
AU - Cañete, Magdalena
PY - 1995/5/8
Y1 - 1995/5/8
N2 - We report on the synthesis of 2,7,12,17-tetraphenylporphycene (TPPo), the first example of an aryl-substituted porphycene macrocycle. A modification of the general porphycene synthetic method has been used, thus avoiding an intermediate sublimation. TPPo has an absorption maximum at 659 nm (ε = 50.000 M-1cm-1), and shows good sensitizing properties: it photoproduces singlet oxygen with a quantum yield of ca. 0.25, is phototoxic to cells, and has low dark toxicity. These properties make TPPo a suitable candidate for the photodynamic therapy of tumors.
AB - We report on the synthesis of 2,7,12,17-tetraphenylporphycene (TPPo), the first example of an aryl-substituted porphycene macrocycle. A modification of the general porphycene synthetic method has been used, thus avoiding an intermediate sublimation. TPPo has an absorption maximum at 659 nm (ε = 50.000 M-1cm-1), and shows good sensitizing properties: it photoproduces singlet oxygen with a quantum yield of ca. 0.25, is phototoxic to cells, and has low dark toxicity. These properties make TPPo a suitable candidate for the photodynamic therapy of tumors.
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U2 - 10.1016/0040-4039(95)00493-V
DO - 10.1016/0040-4039(95)00493-V
M3 - Article
AN - SCOPUS:0028949605
SN - 0040-4039
VL - 36
SP - 3405
EP - 3408
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 19
ER -