Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

Pan Kaj Garg; Shambhavi Pandey; Hong Nam Kim; Hoon Seonwoo; Sunho Park; Kyoung Soon Choi; Kyoung Je Jang; Hoon Hyun; Phil Hoon Choung; Jangho Kim; Jong Hoon Chung

doi:10.1039/c6ra09348e

Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

Pan Kaj Garg
, Shambhavi Pandey
, Hong Nam Kim
, Hoon Seonwoo
, Sunho Park
, Kyoung Soon Choi
, Kyoung Je Jang
, Hoon Hyun
, Phil Hoon Choung^*
, Jangho Kim
, Jong Hoon Chung

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

3 Cites (Scopus)

Resum

Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.

Idioma original	Anglès
Pàgines (de-a)	111233-111238
Nombre de pàgines	6
Revista	RSC Advances
Volum	6
Número	112
DOIs	https://doi.org/10.1039/c6ra09348e
Estat de la publicació	Publicada - 2016
Publicat externament	Sí

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10.1039/c6ra09348e

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title = "Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery",

abstract = "Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.",

keywords = "Mesenchymal stem-cells, Endocytosis, Differentiation, Transfection, Stiffness, Systems, Matrix, Sirna",

author = "Garg, \{Pan Kaj\} and Shambhavi Pandey and Kim, \{Hong Nam\} and Hoon Seonwoo and Sunho Park and Choi, \{Kyoung Soon\} and Jang, \{Kyoung Je\} and Hoon Hyun and Choung, \{Phil Hoon\} and Jangho Kim and Chung, \{Jong Hoon\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6ra09348e",

language = "English",

volume = "6",

pages = "111233--111238",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "112",

}

TY - JOUR

T1 - Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

AU - Garg, Pan Kaj

AU - Pandey, Shambhavi

AU - Kim, Hong Nam

AU - Seonwoo, Hoon

AU - Park, Sunho

AU - Choi, Kyoung Soon

AU - Jang, Kyoung Je

AU - Hyun, Hoon

AU - Choung, Phil Hoon

AU - Kim, Jangho

AU - Chung, Jong Hoon

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.

AB - Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.

KW - Mesenchymal stem-cells

KW - Endocytosis

KW - Differentiation

KW - Transfection

KW - Stiffness

KW - Systems

KW - Matrix

KW - Sirna

UR - https://www.scopus.com/pages/publications/84997765911

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000389463600084&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1039/c6ra09348e

DO - 10.1039/c6ra09348e

M3 - Article

AN - SCOPUS:84997765911

SN - 2046-2069

VL - 6

SP - 111233

EP - 111238

JO - RSC Advances

JF - RSC Advances

IS - 112

ER -

Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

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