Surface charge tunability as a powerful strategy to control electrostatic interaction for high efficiency silencing, using tailored oligopeptide-modified poly(beta-amino ester)s (PBAEs)

Pere Dosta, Nathaly Segovia, Anna Cascante, Victor Ramos, Salvador Borrós

Producció científica: Article en revista indexadaArticleAvaluat per experts

57 Cites (Scopus)

Resum

Here we present an extended family of pBAEs that incorporate terminal oligopeptide moieties synthesized from both positive and negative amino acids. Polymer formulations of mixtures of negative and positive oligopeptide-modified pBAEs are capable of condensing siRNA into discrete nanoparticles. We have demonstrated that efficient delivery of nucleic acids in a cell-type dependent manner can be achieved by careful control of the pBAE formulation. In addition, our approach of adding differently charged oligopeptides to the termini of poly(β-amino ester)s is of great interest for the design of tailored complexes having specific features, such as tuneable zeta potential. We anticipate that this surface charge tunability may be a powerful strategy to control unwanted electrostatic interactions, while preserving high silencing efficiency and reduced toxicity.

Idioma originalAnglès
Pàgines (de-a)82-93
Nombre de pàgines12
RevistaActa Biomaterialia
Volum20
DOIs
Estat de la publicacióPublicada - 1 de jul. 2015

Fingerprint

Navegar pels temes de recerca de 'Surface charge tunability as a powerful strategy to control electrostatic interaction for high efficiency silencing, using tailored oligopeptide-modified poly(beta-amino ester)s (PBAEs)'. Junts formen un fingerprint únic.

Com citar-ho