TY - JOUR
T1 - Spatiotemporal delivery of bioactive molecules for wound healing using stimuli-responsive biomaterials
AU - Oliva, Nuria
AU - Almquist, Benjamin D.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/1
Y1 - 2020/1
N2 - Wound repair is a fascinatingly complex process, with overlapping events in both space and time needed to pave a pathway to successful healing. This additional complexity presents challenges when developing methods for the controlled delivery of therapeutics for wound repair and tissue engineering. Unlike more traditional applications, where biomaterial-based depots increase drug solubility and stability in vivo, enhance circulation times, and improve retention in the target tissue, when aiming to modulate wound healing, there is a desire to enable localised, spatiotemporal control of multiple therapeutics. Furthermore, many therapeutics of interest in the context of wound repair are sensitive biologics (e.g. growth factors), which present unique challenges when designing biomaterial-based delivery systems. Here, we review the diverse approaches taken by the biomaterials community for creating stimuli-responsive materials that are beginning to enable spatiotemporal control over the delivery of therapeutics for applications in tissue engineering and regenerative medicine.
AB - Wound repair is a fascinatingly complex process, with overlapping events in both space and time needed to pave a pathway to successful healing. This additional complexity presents challenges when developing methods for the controlled delivery of therapeutics for wound repair and tissue engineering. Unlike more traditional applications, where biomaterial-based depots increase drug solubility and stability in vivo, enhance circulation times, and improve retention in the target tissue, when aiming to modulate wound healing, there is a desire to enable localised, spatiotemporal control of multiple therapeutics. Furthermore, many therapeutics of interest in the context of wound repair are sensitive biologics (e.g. growth factors), which present unique challenges when designing biomaterial-based delivery systems. Here, we review the diverse approaches taken by the biomaterials community for creating stimuli-responsive materials that are beginning to enable spatiotemporal control over the delivery of therapeutics for applications in tissue engineering and regenerative medicine.
KW - Biomaterials
KW - Controlled release
KW - Drug delivery
KW - Regenerative medicine
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85089258502&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2020.07.021
DO - 10.1016/j.addr.2020.07.021
M3 - Review
C2 - 32745497
AN - SCOPUS:85089258502
SN - 0169-409X
VL - 161-162
SP - 22
EP - 41
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -