Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites

Oscar Molins-Molina, Roger Bresolí-Obach, Guillermo Garcia-Lainez, Inmaculada Andreu, Santi Nonell, Miguel A. Miranda*, M. Consuelo Jiménez

*Autor corresponent d’aquest treball

Producció científica: Article en revista indexadaArticleAvaluat per experts

4 Cites (Scopus)

Resum

Singlet oxygen photosensitization (studied by time-resolved near-infrared emission spectroscopy) and in vitro phototoxicity (by means of the 3T3 neutral red uptake assay) have been investigated for the prodrugs fenofibrate (FFB), mycophenolate mofetil (MMP), and trifusal (TFS) as well as for their active metabolites fenofibric acid (FFA), mycophenolic acid (MPA), and 2-hydroxy-4-(trifluoromethyl)benzoic acid (HTB). The results show that FFB and its active metabolite FFA generate 1O2 with a quantum yield in the range 0.30 to 0.40 and show a photo-irritation factor (PIF) higher than 40. By contrast, MMP/MPA and TFS/HTB are not photoactive in the used assays. These results correlate well with the previously reported in vivo phototoxicity in treated patients.

Idioma originalAnglès
Número d’articlee3722
Nombre de pàgines7
RevistaJournal of Physical Organic Chemistry
Volum30
Número9
DOIs
Estat de la publicacióPublicada - de set. 2017

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