Sildenafil to improve respiratory rehabilitation outcomes in COPD: A controlled trial

Isabel Blanco, Salud Santos, Joaqím Gea, Rosa Güell, Ferran Torres, Elena Gimeno-Santos, Diego A. Rodriguez, Jordi Vilaró, Begona Gómez, Josep Roca, Joan Albert Barberà

Producció científica: Article en revista indexadaArticleAvaluat per experts

139 Cites (Scopus)

Resum

Pulmonary hypertension is a serious complication of chronic obstructive pulmonary disease (COPD) that currently has no established pharmacological treatment. This study aimed to assess whether concomitant treatment with sildenafil would enhance the results of pulmonary rehabilitation in patients with COPD and increased pulmonary arterial pressure (PAP). In this double-blind, randomised controlled trial patients received 20 mg sildenafil or placebo three times daily and underwent pulmonary rehabilitation for 3 months. The primary end-point was the gain in the cycle endurance time at a constant work-rate. Secondary end-points included performance in the incremental exercise test, 6-min walk distance and quality of life. 63 patients with severe COPD and moderately increased PAP were randomised. Cycle endurance time increased by 149 s (95% CI 26-518 s) in the sildenafil group and by 169 s (95% CI 0-768 s) in the placebo group (median change difference -7 s, 95% CI -540-244 s; p=0.77). Gains in the incremental exercise test, 6-min walk distance and quality of life at the end of the study did not differ between groups. Measurements of arterial oxygenation and adverse events were similar in both groups. In patients with severe COPD and moderately increased PAP, concomitant treatment with sildenafil does not improve the results of pulmonary rehabilitation in exercise tolerance.

Idioma originalAnglès
Pàgines (de-a)982-992
Nombre de pàgines11
RevistaEuropean Respiratory Journal
Volum42
Número4
DOIs
Estat de la publicacióPublicada - 1 d’oct. 2013

Fingerprint

Navegar pels temes de recerca de 'Sildenafil to improve respiratory rehabilitation outcomes in COPD: A controlled trial'. Junts formen un fingerprint únic.

Com citar-ho