Sequential copper-catalyzed vinylation/ cyclization: An efficient synthesis of functionalized oxazoles

Rubén Martín, Ana Cuenca, Stephen L. Buchwald

Producció científica: Article en revista indexadaArticleAvaluat per experts

137 Cites (Scopus)

Resum

A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.

Idioma originalAnglès
Pàgines (de-a)5521-5524
Nombre de pàgines4
RevistaOrganic Letters
Volum9
Número26
DOIs
Estat de la publicacióPublicada - 20 de des. 2007
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