Self-Assembling Peptides as Synthetic Extracellular Matrices

M. T. Fernandez Muiños, C. E. Semino

Producció científica: Capítol de llibreCapítolAvaluat per experts


The self-assembling of biomolecules is a phenomenon commonly observed in biology, from DNA self-complementary double helix annealing, through protein aggregation or lipid membrane formation. Among them are included the proteins forming the extracellular matrix (ECM) of connective tissues, such as collagens, laminins, and fibronectins. Several self-assembling peptides have been molecular designed taking the assembling principles of Lysβ-21 and EAK16 as reference. The RAD16-I is used in this chapter to illustrate the self-assembling process. Currently, the use of self-assembling peptides has been implemented and verified to be an excellent scaffold for both in vitro and in vivo applications. The chapter first reviews several in vitro studies. Some of them involve the functional maintenance of hepatocytes in vitro, which is a major challenge since these cells rapidly lose their metabolic properties in culture.

Idioma originalAnglès
Títol de la publicacióPolymers in Regenerative Medicine
Subtítol de la publicacióBiomedical Applications from Nano- to Macro-Structures
Nombre de pàgines13
ISBN (electrònic)9781118356692
ISBN (imprès)9780470596388
Estat de la publicacióPublicada - 30 de gen. 2014


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