TY - JOUR
T1 - Self-assembling peptide scaffolds as innovative platforms for drug and cell delivery systems in cardiac regeneration
AU - Puig-Sanvicens, Veronica A.C.
AU - Semino, Carlos E.
N1 - Funding Information:
BTC2009/2010-0010-AND Fellowship Grant from the Government of Andorra to VACPS is greatly acknowledged. The authors of this work want to thank to the European Union, Seventh Framework Program (7FP/2007-2013) for funding received with the project RECATABI to CES under grant agreement no. 229239.
PY - 2013/8
Y1 - 2013/8
N2 - Today, the use of biomaterials in many biomedical platforms is becoming increasingly popular due to their high diversity, infinite mimicking capacity, and emerging functions. Applications currently cover diverse areas in biomedicine including systems for cell isolation, expansion and maintenance, platforms for drug and cell delivery, scaffolds for tissue engineering, tissue regeneration and repair, cancer therapy, etc. Biomaterials in general can be: (1) natural in origin such as many proteins from the extracellular matrix, natural polysaccharides or scaffolds presented in a blood clot or (2) synthetic, including polymers, ceramics, or peptides. In this review, we focus on the use of self-assembling peptide scaffolds as an innovative and reliable strategy to obtain platforms for cell and drug delivery to injured or diseased tissues and organs. This type of material is molecular by design and it develops spontaneously into nanofiber scaffolds with multiple uses. In particular, examples are given for applications in the area of cardiac repair and regeneration.
AB - Today, the use of biomaterials in many biomedical platforms is becoming increasingly popular due to their high diversity, infinite mimicking capacity, and emerging functions. Applications currently cover diverse areas in biomedicine including systems for cell isolation, expansion and maintenance, platforms for drug and cell delivery, scaffolds for tissue engineering, tissue regeneration and repair, cancer therapy, etc. Biomaterials in general can be: (1) natural in origin such as many proteins from the extracellular matrix, natural polysaccharides or scaffolds presented in a blood clot or (2) synthetic, including polymers, ceramics, or peptides. In this review, we focus on the use of self-assembling peptide scaffolds as an innovative and reliable strategy to obtain platforms for cell and drug delivery to injured or diseased tissues and organs. This type of material is molecular by design and it develops spontaneously into nanofiber scaffolds with multiple uses. In particular, examples are given for applications in the area of cardiac repair and regeneration.
KW - Cardiac regeneration
KW - Cell delivery
KW - Drug delivery
KW - Self-assembling peptide scaffold
UR - http://www.scopus.com/inward/record.url?scp=84879536152&partnerID=8YFLogxK
U2 - 10.1007/s13346-012-0125-8
DO - 10.1007/s13346-012-0125-8
M3 - Review
AN - SCOPUS:84879536152
SN - 2190-393X
VL - 3
SP - 330
EP - 335
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
IS - 4
ER -
