Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

David J. Hughes, Veronika Fedirko, Mazda Jenab, Lutz Schomburg, Catherine Méplan, Heinz Freisling, H. Bas Bueno-De-Mesquita, Sandra Hybsier, Niels Peter Becker, Magdalena Czuban, Anne Tjønneland, Malene Outzen, Marie Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman Kühn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona LagiouSalvatore Panico, Petra H. Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria Dolores Chirlaque, Maria Jose Sánchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E. Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ramón Quirós, Magdalena Stepien, So Yeon Kong, Talita Duarte-Salles, Elio Riboli, John E. Hesketh

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Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μ/L and 4.3 mg/L in cases and 85.6 μ/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR=0.92, 95% CI: 0.82-1.03 per 25 lg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (ptrend=0.032; per 25 μ/L Se increase, IRR=0.83, 95% CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (ptrend=0.009; per 0.806 mg/L increase, IRR50.89, 95% CI: 0.82-0.98) with the association more apparent in women (ptrend=0.004; IRR=0.82, 95% CI: 0.72-0.94 per 0.806 mg/L increase) than men (ptrend50.485; IRR50.98, 95% CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.

Idioma originalAnglès
Pàgines (de-a)1149-1161
Nombre de pàgines13
RevistaInternational Journal of Cancer
Estat de la publicacióPublicada - 1 de març 2015
Publicat externament


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